open access

Vol 44, No 1 (2010)
ARTYKUŁ ORYGINALNY
Submitted: 2009-09-17
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Radiation therapy in paediatric gliomas: our institutional experience

Daya Nand Sharma, Shikha Goyal, Sandeep Muzumder, Kunhi Parambath Haresh, Amit Bahl, Parmod Kumar Julka, Goura Kisor Rath
DOI: 10.1016/S0028-3843(14)60404-7
·
Neurol Neurochir Pol 2010;44(1):28-34.

open access

Vol 44, No 1 (2010)
ARTYKUŁ ORYGINALNY
Submitted: 2009-09-17

Abstract

Background and purpose

The aim of our retrospective study was to analyze the clinical outcome of paediatric glioma patients treated with radiation therapy (RT) in our institution.

Material and methods

We retrieved the case records of all children with gliomas (age < 18 years) who received RT in our department between 2004 and 2007. We analyzed the information regarding patients' demography, clinical details, treatment given, RT details, and survival. The event-free survival (EFS), the period from the date of completion of RT to the date of the event, i.e. death/recurrence, was calculated with respect to age, sex, location of tumour (brainstem vs. non-brainstem), histopathology (low grade vs. high grade), extent of surgical resection, dose and duration of RT, and use of chemotherapy.

Results

A total of 70 children with glioma received RT during the above-mentioned period. The 3-year EFS rate for all patients was 44% and the median EFS period was 18 months. The 3-year EFS in patients who underwent surgical decompression and no surgery was 58% and 25%, respectively (p < 0.05). Patients with brainstem lesions had statistically significantly lower 3-year EFS to non-brainstem gliomas (28% vs. 56%, p < 0.01). Chemotherapy use showed no statistically significant trend towards better survival.

Conclusions

RT is an effective modality of treatment in paediatric glioma patients in our setup. Early use of RT in incompletely resected low-grade gliomas is worth revisiting. Results of chemotherapy in high-grade glioma and brainstem gliomas are encouraging.

Abstract

Background and purpose

The aim of our retrospective study was to analyze the clinical outcome of paediatric glioma patients treated with radiation therapy (RT) in our institution.

Material and methods

We retrieved the case records of all children with gliomas (age < 18 years) who received RT in our department between 2004 and 2007. We analyzed the information regarding patients' demography, clinical details, treatment given, RT details, and survival. The event-free survival (EFS), the period from the date of completion of RT to the date of the event, i.e. death/recurrence, was calculated with respect to age, sex, location of tumour (brainstem vs. non-brainstem), histopathology (low grade vs. high grade), extent of surgical resection, dose and duration of RT, and use of chemotherapy.

Results

A total of 70 children with glioma received RT during the above-mentioned period. The 3-year EFS rate for all patients was 44% and the median EFS period was 18 months. The 3-year EFS in patients who underwent surgical decompression and no surgery was 58% and 25%, respectively (p < 0.05). Patients with brainstem lesions had statistically significantly lower 3-year EFS to non-brainstem gliomas (28% vs. 56%, p < 0.01). Chemotherapy use showed no statistically significant trend towards better survival.

Conclusions

RT is an effective modality of treatment in paediatric glioma patients in our setup. Early use of RT in incompletely resected low-grade gliomas is worth revisiting. Results of chemotherapy in high-grade glioma and brainstem gliomas are encouraging.

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Keywords

paediatric glioma, radiation therapy, retrospective analysis

About this article
Title

Radiation therapy in paediatric gliomas: our institutional experience

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 44, No 1 (2010)

Pages

28-34

DOI

10.1016/S0028-3843(14)60404-7

Bibliographic record

Neurol Neurochir Pol 2010;44(1):28-34.

Keywords

paediatric glioma
radiation therapy
retrospective analysis

Authors

Daya Nand Sharma
Shikha Goyal
Sandeep Muzumder
Kunhi Parambath Haresh
Amit Bahl
Parmod Kumar Julka
Goura Kisor Rath

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