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Impact of proliferative stress on both adaptive and innate immune response
Affiliations- Department of Hematology and Transplantology, Medical University of Gdańsk, Poland
- Department of Physiopathology, Medical University of Gdańsk, Poland
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Abstract
Human ageing is by far one of the most complex biological phenomena which affects all cells and tissues, leading to gradual loss of function, decrement in proliferative activity, and impaired cellular response. One of the key mechanisms of cellular ageing is proliferative stress which results in telomeric attrition, DNA damage, and deposition of senescence-associated proteins. Allogeneic hematopoietic cells transplantation (allo-HCT) serves as a good model for cellular ageing. Here we review the ageing of the immune system and the impact of proliferative stress on both innate and adaptive immune response, reflected by immunosenescence and inflammageing phenomena, in the context of iatrogenic proliferative stress induced by allo-HCT.
Abstract
Human ageing is by far one of the most complex biological phenomena which affects all cells and tissues, leading to gradual loss of function, decrement in proliferative activity, and impaired cellular response. One of the key mechanisms of cellular ageing is proliferative stress which results in telomeric attrition, DNA damage, and deposition of senescence-associated proteins. Allogeneic hematopoietic cells transplantation (allo-HCT) serves as a good model for cellular ageing. Here we review the ageing of the immune system and the impact of proliferative stress on both innate and adaptive immune response, reflected by immunosenescence and inflammageing phenomena, in the context of iatrogenic proliferative stress induced by allo-HCT.
Keywords
immunosenescence; inflammageing; allo-HCT; proliferative stress
About this articleTitle
Impact of proliferative stress on both adaptive and innate immune response
Journal
Journal of Transfusion Medicine
Issue
Article type
Review paper
Pages
91-96
Published online
2023-04-28
Page views
923
Article views/downloads
86
DOI
Bibliographic record
Journal of Transfusion Medicine 2023;16(2):91-96.
Keywords
immunosenescence
inflammageing
allo-HCT
proliferative stress
Authors
Michał Cezary Czarnogórski
Jacek M. Witkowski
Jan M. Zaucha Zaucha
