open access
Practical aspects of HBsAg quantification. Data presented at the seminar “Advances in blood donor screening” (Warsaw, 5–6 October 2015)
open access
Abstract
Quantification of HBsAg is an important clinical marker of chronic hepatitis B activity. So far it is the only noninvasive indicator of cccDNA activity and severity of HBV infection of hepatocytes. A dynamic change of serum HBsAg levels, regardless of the type of administered therapy or in the natural course of chronic hepatitis B, might be predictive of HBsAg-loss which is the optimal end-point of HBV-infection. It is valid not only for current therapies but also for those in development. The most comprehensive knowledge of clinical application of HBsAg quantification has been gained during PEG-IFN therapy. This review focuses on the practical aspects of HBsAg quantification.
Abstract
Quantification of HBsAg is an important clinical marker of chronic hepatitis B activity. So far it is the only noninvasive indicator of cccDNA activity and severity of HBV infection of hepatocytes. A dynamic change of serum HBsAg levels, regardless of the type of administered therapy or in the natural course of chronic hepatitis B, might be predictive of HBsAg-loss which is the optimal end-point of HBV-infection. It is valid not only for current therapies but also for those in development. The most comprehensive knowledge of clinical application of HBsAg quantification has been gained during PEG-IFN therapy. This review focuses on the practical aspects of HBsAg quantification.
Keywords
quantification of HBsAg, marker of chronic hepatitis B activity, noninvasive indicator of cccDNA activity
About this articleTitle
Practical aspects of HBsAg quantification. Data presented at the seminar “Advances in blood donor screening” (Warsaw, 5–6 October 2015)
Journal
Journal of Transfusion Medicine
Issue
Article type
Review paper
Pages
6-9
Published online
2016-04-13
Bibliographic record
Journal of Transfusion Medicine 2016;9(1):6-9.
Keywords
quantification of HBsAg
marker of chronic hepatitis B activity
noninvasive indicator of cccDNA activity
Authors
Jerzy Jaroszewicz