open access

Vol 9, No 1 (2016)
Review paper
Published online: 2016-04-13
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Practical aspects of HBsAg quantification. Data presented at the seminar “Advances in blood donor screening” (Warsaw, 5–6 October 2015)

Jerzy Jaroszewicz
Journal of Transfusion Medicine 2016;9(1):6-9.

open access

Vol 9, No 1 (2016)
REVIEWS
Published online: 2016-04-13

Abstract

Quantification of HBsAg is an important clinical marker of chronic hepatitis B activity. So far it is the only noninvasive indicator of cccDNA activity and severity of HBV infection of hepatocytes. A dynamic change of serum HBsAg levels, regardless of the type of administered therapy or in the natural course of chronic hepatitis B, might be predictive of HBsAg-loss which is the optimal end-point of HBV-infection. It is valid not only for current therapies but also for those in development. The most comprehensive knowledge of clinical application of HBsAg quantification has been gained during PEG-IFN therapy. This review focuses on the practical aspects of HBsAg quantification.

Abstract

Quantification of HBsAg is an important clinical marker of chronic hepatitis B activity. So far it is the only noninvasive indicator of cccDNA activity and severity of HBV infection of hepatocytes. A dynamic change of serum HBsAg levels, regardless of the type of administered therapy or in the natural course of chronic hepatitis B, might be predictive of HBsAg-loss which is the optimal end-point of HBV-infection. It is valid not only for current therapies but also for those in development. The most comprehensive knowledge of clinical application of HBsAg quantification has been gained during PEG-IFN therapy. This review focuses on the practical aspects of HBsAg quantification.

Get Citation

Keywords

quantification of HBsAg, marker of chronic hepatitis B activity, noninvasive indicator of cccDNA activity

About this article
Title

Practical aspects of HBsAg quantification. Data presented at the seminar “Advances in blood donor screening” (Warsaw, 5–6 October 2015)

Journal

Journal of Transfusion Medicine

Issue

Vol 9, No 1 (2016)

Article type

Review paper

Pages

6-9

Published online

2016-04-13

Bibliographic record

Journal of Transfusion Medicine 2016;9(1):6-9.

Keywords

quantification of HBsAg
marker of chronic hepatitis B activity
noninvasive indicator of cccDNA activity

Authors

Jerzy Jaroszewicz

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