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Published online: 2020-07-09
Submitted: 2020-04-02
Accepted: 2020-07-01
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The distribution of ghrelin cells in the human and animal gastrointestinal tract: a review of the evidence

K. M. Mehdar
DOI: 10.5603/FM.a2020.0077
·
Pubmed: 32644180

open access

Ahead of Print
REVIEW ARTICLES
Published online: 2020-07-09
Submitted: 2020-04-02
Accepted: 2020-07-01

Abstract

The growth hormone and appetite are regulated by a 28-peptide hormone called ghrelin, which is produced in the stomach, pituitary gland, and other body tissues. The physiological roles fulfilled by ghrelin include regulation of food intake, cardiac output, reproductive system, proliferation of cells, and formation of osteoblasts, as well as action against inflammation/fibrosis. The ghrelin present in the body can be distinguished as acylated ghrelin and deacylated ghrelin. Furthermore, both in humans and other animals, the entirety of the gastrointestinal tract comprises ghrelin cells, which are classified as open-type and closed-type cells. The present study reviews the evidence about how ghrelin cells are distributed in the human and the animal body.

Abstract

The growth hormone and appetite are regulated by a 28-peptide hormone called ghrelin, which is produced in the stomach, pituitary gland, and other body tissues. The physiological roles fulfilled by ghrelin include regulation of food intake, cardiac output, reproductive system, proliferation of cells, and formation of osteoblasts, as well as action against inflammation/fibrosis. The ghrelin present in the body can be distinguished as acylated ghrelin and deacylated ghrelin. Furthermore, both in humans and other animals, the entirety of the gastrointestinal tract comprises ghrelin cells, which are classified as open-type and closed-type cells. The present study reviews the evidence about how ghrelin cells are distributed in the human and the animal body.

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Keywords

ghrelin, mucous membrane, stomach, gastrointestinal tract, gastric

About this article
Title

The distribution of ghrelin cells in the human and animal gastrointestinal tract: a review of the evidence

Journal

Folia Morphologica

Issue

Ahead of Print

Article type

Review article

Published online

2020-07-09

DOI

10.5603/FM.a2020.0077

Pubmed

32644180

Keywords

ghrelin
mucous membrane
stomach
gastrointestinal tract
gastric

Authors

K. M. Mehdar

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