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Vol 80, No 2 (2021)
Review article
Submitted: 2020-04-02
Accepted: 2020-07-01
Published online: 2020-07-09
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The distribution of ghrelin cells in the human and animal gastrointestinal tract: a review of the evidence
1
Affiliations- Najran University, East of Airport, Najran, Saudi Arabia
open access
Vol 80, No 2 (2021)
REVIEW ARTICLES
Submitted: 2020-04-02
Accepted: 2020-07-01
Published online: 2020-07-09
Abstract
The growth hormone and appetite are regulated by a 28-peptide hormone called ghrelin, which is produced in the stomach, pituitary gland, and other body tissues. The physiological roles fulfilled by ghrelin include regulation of food intake, cardiac output, reproductive system, proliferation of cells, and formation of osteoblasts, as well as action against inflammation/fibrosis. The ghrelin present in the body can be distinguished as acylated ghrelin and deacylated ghrelin. Furthermore, both in humans and other animals, the entirety of the gastrointestinal tract comprises ghrelin cells, which are classified as open-type and closed-type cells. The present study reviews the evidence about how ghrelin cells are distributed in the human and the animal body.
Abstract
The growth hormone and appetite are regulated by a 28-peptide hormone called ghrelin, which is produced in the stomach, pituitary gland, and other body tissues. The physiological roles fulfilled by ghrelin include regulation of food intake, cardiac output, reproductive system, proliferation of cells, and formation of osteoblasts, as well as action against inflammation/fibrosis. The ghrelin present in the body can be distinguished as acylated ghrelin and deacylated ghrelin. Furthermore, both in humans and other animals, the entirety of the gastrointestinal tract comprises ghrelin cells, which are classified as open-type and closed-type cells. The present study reviews the evidence about how ghrelin cells are distributed in the human and the animal body.
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Keywords
ghrelin, mucous membrane, stomach, gastrointestinal tract, gastric
About this articleTitle
The distribution of ghrelin cells in the human and animal gastrointestinal tract: a review of the evidence
Journal
Issue
Article type
Review article
Pages
225-236
Published online
2020-07-09
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1503
Article views/downloads
1791
DOI
Pubmed
Bibliographic record
Folia Morphol 2021;80(2):225-236.
Keywords
ghrelin
mucous membrane
stomach
gastrointestinal tract
gastric
Authors
K. M. Mehdar
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