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Vol 2, No 1 (2006)
Prace oryginalne
Published online: 2006-02-07
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Evaluation of insulin resistance with euglicemic clamp in obese patients

Monika Szulińska, Danuta Pupek-Musialik, Paweł Bogdański, Anna Miczke, Wiesław Bryl
Endokrynol. Otył. Zab. Przem. Mat 2006;2(1):5-11.

open access

Vol 2, No 1 (2006)
Prace oryginalne
Published online: 2006-02-07

Abstract

INTRODUCTION. Obesity is an important public health problem. Its prevalence has been steadily increasing during recent years, especially in industrialised societies. Insulin resistance plays a fundamental role in complex pathogenesis of obesity complications. The aim of the study was to evaluate concentrations of insulin and value of insulin sensitivity in patients with obesity. The relationship between insulin, insulin sensitivity ratio and selected biochemical and anthropometric parametrs were also studied.
MATERIAL AND METHODS. 30 obese patients were qualified for the study. 15 healthy lean volunteers were used as a control group. Each subject underwent physical examination. Anthropometric parameters (body mass index - BMI, wais, hip circumference, waist to hip ratio - WHR) were measured. The percentage of fat content (%FAT) were assessed by bioimpedancy method with Bodystat 1500 apparatus. Routine laboratory tests were performed too. Insulin concentrations were determined by radioimmunoassay. Insulin sensitivity value (M) was calculated after euglicemic clamp.
RESULTS. Serum level of insulin in the studied group was significantly higher and insulin sensitivity ratio M significantly lower in compared with the control group.
In obese patients the following correlations were found:
• positive correlations between logarithm of insulin (lnINS) and BMI, lnTG, %FAT, WHR;
• negative correlations between logarithm insulin sensitivity ratio M and BMI, waist, lnHDL, %FAT.
CONCLUSIONS:
1. Obesity is associated with increased plasma insulin and insulin resistance.
2. Insulin resistance level depends on fat content and waist circumference.
3. Correlations between insulin sensitivity ratio M and lnHDL and lnTG indicates insulin resistance role in pathogenesis of lipids complications in obese patients.

Abstract

INTRODUCTION. Obesity is an important public health problem. Its prevalence has been steadily increasing during recent years, especially in industrialised societies. Insulin resistance plays a fundamental role in complex pathogenesis of obesity complications. The aim of the study was to evaluate concentrations of insulin and value of insulin sensitivity in patients with obesity. The relationship between insulin, insulin sensitivity ratio and selected biochemical and anthropometric parametrs were also studied.
MATERIAL AND METHODS. 30 obese patients were qualified for the study. 15 healthy lean volunteers were used as a control group. Each subject underwent physical examination. Anthropometric parameters (body mass index - BMI, wais, hip circumference, waist to hip ratio - WHR) were measured. The percentage of fat content (%FAT) were assessed by bioimpedancy method with Bodystat 1500 apparatus. Routine laboratory tests were performed too. Insulin concentrations were determined by radioimmunoassay. Insulin sensitivity value (M) was calculated after euglicemic clamp.
RESULTS. Serum level of insulin in the studied group was significantly higher and insulin sensitivity ratio M significantly lower in compared with the control group.
In obese patients the following correlations were found:
• positive correlations between logarithm of insulin (lnINS) and BMI, lnTG, %FAT, WHR;
• negative correlations between logarithm insulin sensitivity ratio M and BMI, waist, lnHDL, %FAT.
CONCLUSIONS:
1. Obesity is associated with increased plasma insulin and insulin resistance.
2. Insulin resistance level depends on fat content and waist circumference.
3. Correlations between insulin sensitivity ratio M and lnHDL and lnTG indicates insulin resistance role in pathogenesis of lipids complications in obese patients.
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Keywords

obesity; insulin sensitivity; insulin; dyslipidaemia

About this article
Title

Evaluation of insulin resistance with euglicemic clamp in obese patients

Journal

Endocrinology, Obesity and Metabolic Disorders

Issue

Vol 2, No 1 (2006)

Pages

5-11

Published online

2006-02-07

Page views

1036

Article views/downloads

9745

Bibliographic record

Endokrynol. Otył. Zab. Przem. Mat 2006;2(1):5-11.

Keywords

obesity
insulin sensitivity
insulin
dyslipidaemia

Authors

Monika Szulińska
Danuta Pupek-Musialik
Paweł Bogdański
Anna Miczke
Wiesław Bryl

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