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Is oxidative stress a factor in the pathogenesis of subacute thyroiditis?
, 1, 1, 2, 2, 1
Affiliations- Department of Endocrinology and Metabolism, Keçiören Health Administration and Research Centre, University of Health Sciences, Ankara, Turkey
- Department of Medical Biochemistry, University of Yıldırım Beyazıt, Ankara, Turkey
open access
Abstract
Introduction: In a performed study, selenium levels were detected to be lower in subacute thyroiditis (SAT). This outcome suggests that the oxidant-antioxidant system may play a role in the aetiopathogenesis of SAT, as is the case for many other diseases. The aim of the present study was to detect whether any association exists between SAT and oxidative stress, and to determine the factors of a possible association.
Material and methods: Twenty-five patients who were newly diagnosed with SAT and 30 healthy volunteers were enrolled in the study. Total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), paraoxonase 1 (PON1), and dynamic thiol/disulphide [native thiol (NT), total thiol (TT), disulphide (DS), DS/TT, DS/NT, and NT/TT] levels of the participants were evaluated.
Results: Total thiol and NT levels were found to be lower in the SAT group (p < 0.001). DS/NT and DS/TT levels were significantly higher in the patients with SAT, whereas NT/TT levels were lower (p < 0.05). A negative correlation was detected between C-reactive protein (CRP) and TAS, whereas a positive correlation was detected between CRP and OSI. There was a negative association between TSH and TAS only in the partial correlation analysis by adjusting for age, white blood cell count, neutrophil (Neu) level, CRP, and erythrocyte sedimentation rate (ESR) (r = –0.481, p = 0.043).
Conclusions: Thiol levels are significantly decreased and thiol/disulphide homoeostasis is disrupted in patients with SAT. The present study has presented for the first time that there may be an association between SAT and oxidative stress.
Abstract
Introduction: In a performed study, selenium levels were detected to be lower in subacute thyroiditis (SAT). This outcome suggests that the oxidant-antioxidant system may play a role in the aetiopathogenesis of SAT, as is the case for many other diseases. The aim of the present study was to detect whether any association exists between SAT and oxidative stress, and to determine the factors of a possible association.
Material and methods: Twenty-five patients who were newly diagnosed with SAT and 30 healthy volunteers were enrolled in the study. Total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), paraoxonase 1 (PON1), and dynamic thiol/disulphide [native thiol (NT), total thiol (TT), disulphide (DS), DS/TT, DS/NT, and NT/TT] levels of the participants were evaluated.
Results: Total thiol and NT levels were found to be lower in the SAT group (p < 0.001). DS/NT and DS/TT levels were significantly higher in the patients with SAT, whereas NT/TT levels were lower (p < 0.05). A negative correlation was detected between C-reactive protein (CRP) and TAS, whereas a positive correlation was detected between CRP and OSI. There was a negative association between TSH and TAS only in the partial correlation analysis by adjusting for age, white blood cell count, neutrophil (Neu) level, CRP, and erythrocyte sedimentation rate (ESR) (r = –0.481, p = 0.043).
Conclusions: Thiol levels are significantly decreased and thiol/disulphide homoeostasis is disrupted in patients with SAT. The present study has presented for the first time that there may be an association between SAT and oxidative stress.
Keywords
subacute thyroiditis; pathogenesis; oxidative stress; inflammation; dynamic thiol/disulphide
About this articleTitle
Is oxidative stress a factor in the pathogenesis of subacute thyroiditis?
Journal
Issue
Article type
Original paper
Pages
64-70
Published online
2022-02-08
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5512
Article views/downloads
596
DOI
Pubmed
Bibliographic record
Endokrynol Pol 2022;73(1):64-70.
Keywords
subacute thyroiditis
pathogenesis
oxidative stress
inflammation
dynamic thiol/disulphide
Authors
Murat Dağdeviren
Arzu Or Koca
Tolga Akkan
Salim Neşelioğlu
Özcan Erel
Mustafa Altay
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