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Vol 71, No 5 (2020)
Review paper
Submitted: 2020-05-25
Accepted: 2020-06-27
Published online: 2020-10-30
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An overview of biological research on hypoxia-inducible factors (HIFs)
1
, 2, 1, 1
, 2, 1, 1
Affiliations- Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Shanghai University of Finance and Economics, Shanghai, China
open access
Vol 71, No 5 (2020)
Review Article
Submitted: 2020-05-25
Accepted: 2020-06-27
Published online: 2020-10-30
Abstract
Hypoxia-inducible factors (HIFs), as a family of transcription factors involved in the cellular response to hypoxia, are key regulatory factors in the regulation mechanism of an organism’s response to hypoxia. A large number of studies have shown that HIFs are closely related to the angiogenesis, erythropoiesis, cell metabolism, and autophagy of organisms, as well as the occurrence and development of tumours. Therefore, it is of great significance to further study HIFs to understand and treat tumours or other related diseases. This paper summarises the structure, oxygen-dependent degradation mechanism, non-oxygen-dependent degradation mechanism, transcriptional activation mechanism, relevant signalling pathways, and inhibitors of HIFs, in order to provide new clues for the treatment of tumour, vascular, and other related diseases.
Abstract
Hypoxia-inducible factors (HIFs), as a family of transcription factors involved in the cellular response to hypoxia, are key regulatory factors in the regulation mechanism of an organism’s response to hypoxia. A large number of studies have shown that HIFs are closely related to the angiogenesis, erythropoiesis, cell metabolism, and autophagy of organisms, as well as the occurrence and development of tumours. Therefore, it is of great significance to further study HIFs to understand and treat tumours or other related diseases. This paper summarises the structure, oxygen-dependent degradation mechanism, non-oxygen-dependent degradation mechanism, transcriptional activation mechanism, relevant signalling pathways, and inhibitors of HIFs, in order to provide new clues for the treatment of tumour, vascular, and other related diseases.
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Keywords
HIFs; biological research
About this articleTitle
An overview of biological research on hypoxia-inducible factors (HIFs)
Journal
Issue
Article type
Review paper
Pages
432-440
Published online
2020-10-30
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1349
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1303
DOI
Pubmed
Bibliographic record
Endokrynol Pol 2020;71(5):432-440.
Keywords
HIFs
biological research
Authors
Zhe Liu
Zixuan Wu
Yuxin Fan
Yudong Fang
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