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The role of genetic risk factors, diet, and gut microbiota in type 1 diabetes mellitus, pancreas and pancreatic islet transplantation
, 3, 3, 41, 41, 5, 1, 41
Affiliations- Department of Gastroenterology, Dietetics, and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland
- Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland
- The Transplantation Institute, University of Chicago, Chicago, United States
- Laboratory of Nutrigenetics, Department of Gastroenterology, Dietetics, and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland
- Department of General and Transplantation Surgery, Poznan University of Medical Sciences, Poznan, Poland
open access
Abstract
Despite advances in insulin delivery and glucose monitoring technology, prevention of the progression of secondary complications in patients with type 1 diabetes (T1DM) remains a challenge. Beta cell replacement therapy in the form of islet or pancreas transplantation can restore long-term normoglycaemia with sustained periods of insulin independence among T1DM patients.
However, the same genetic, behavioural, or gut microbiota-related factors that promoted autoimmunity and primary islet destruction may also affect the function of transplanted islets and the ultimate results of transplant procedures. In such cases, identifying genetic risk factors and modifying behavioural factors and those related to gut microbiota may be beneficial for the outcomes of transplant procedures.
Herein, we review related literature to the identified current gap in knowledge to be addressed in future clinical trials.
Abstract
Despite advances in insulin delivery and glucose monitoring technology, prevention of the progression of secondary complications in patients with type 1 diabetes (T1DM) remains a challenge. Beta cell replacement therapy in the form of islet or pancreas transplantation can restore long-term normoglycaemia with sustained periods of insulin independence among T1DM patients.
However, the same genetic, behavioural, or gut microbiota-related factors that promoted autoimmunity and primary islet destruction may also affect the function of transplanted islets and the ultimate results of transplant procedures. In such cases, identifying genetic risk factors and modifying behavioural factors and those related to gut microbiota may be beneficial for the outcomes of transplant procedures.
Herein, we review related literature to the identified current gap in knowledge to be addressed in future clinical trials.
Keywords
pancreatic islets transplantation; genes; gut microbiota; diet; type 1 diabetes
About this articleTitle
The role of genetic risk factors, diet, and gut microbiota in type 1 diabetes mellitus, pancreas and pancreatic islet transplantation
Journal
Issue
Article type
Review paper
Pages
140-147
Published online
2024-04-22
Page views
191
Article views/downloads
100
DOI
Pubmed
Bibliographic record
Endokrynol Pol 2024;75(2):140-147.
Keywords
pancreatic islets transplantation
genes
gut microbiota
diet
type 1 diabetes
Authors
Agnieszka Zawada
Marzena Skrzypczak-Zielińska
Sarah Gondek
Piotr Witkowski
Anna M. Rychter
Alicja E. Ratajczak-Pawłowska
Marek Karczewski
Agnieszka Dobrowolska
Iwona Krela-Kaźmierczak
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