open access

Vol 73, No 1 (2022)
Original paper
Submitted: 2021-09-11
Accepted: 2021-10-21
Published online: 2022-02-08
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Is oxidative stress a factor in the pathogenesis of subacute thyroiditis?

Murat Dağdeviren1, Arzu Or Koca1, Tolga Akkan1, Salim Neşelioğlu2, Özcan Erel2, Mustafa Altay1
·
Pubmed: 35156704
·
Endokrynol Pol 2022;73(1):64-70.
Affiliations
  1. Department of Endocrinology and Metabolism, Keçiören Health Administration and Research Centre, University of Health Sciences, Ankara, Turkey
  2. Department of Medical Biochemistry, University of Yıldırım Beyazıt, Ankara, Turkey

open access

Vol 73, No 1 (2022)
Original Paper
Submitted: 2021-09-11
Accepted: 2021-10-21
Published online: 2022-02-08

Abstract

Introduction: In a performed study, selenium levels were detected to be lower in subacute thyroiditis (SAT). This outcome suggests that the oxidant-antioxidant system may play a role in the aetiopathogenesis of SAT, as is the case for many other diseases. The aim of the present study was to detect whether any association exists between SAT and oxidative stress, and to determine the factors of a possible association.

Material and methods: Twenty-five patients who were newly diagnosed with SAT and 30 healthy volunteers were enrolled in the study. Total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), paraoxonase 1 (PON1), and dynamic thiol/disulphide [native thiol (NT), total thiol (TT), disulphide (DS), DS/TT, DS/NT, and NT/TT] levels of the participants were evaluated.

Results: Total thiol and NT levels were found to be lower in the SAT group (p < 0.001). DS/NT and DS/TT levels were significantly higher in the patients with SAT, whereas NT/TT levels were lower (p < 0.05). A negative correlation was detected between C-reactive protein (CRP) and TAS, whereas a positive correlation was detected between CRP and OSI. There was a negative association between TSH and TAS only in the partial correlation analysis by adjusting for age, white blood cell count, neutrophil (Neu) level, CRP, and erythrocyte sedimentation rate (ESR) (r = –0.481, p = 0.043).

Conclusions: Thiol levels are significantly decreased and thiol/disulphide homoeostasis is disrupted in patients with SAT. The present study has presented for the first time that there may be an association between SAT and oxidative stress.

Abstract

Introduction: In a performed study, selenium levels were detected to be lower in subacute thyroiditis (SAT). This outcome suggests that the oxidant-antioxidant system may play a role in the aetiopathogenesis of SAT, as is the case for many other diseases. The aim of the present study was to detect whether any association exists between SAT and oxidative stress, and to determine the factors of a possible association.

Material and methods: Twenty-five patients who were newly diagnosed with SAT and 30 healthy volunteers were enrolled in the study. Total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), paraoxonase 1 (PON1), and dynamic thiol/disulphide [native thiol (NT), total thiol (TT), disulphide (DS), DS/TT, DS/NT, and NT/TT] levels of the participants were evaluated.

Results: Total thiol and NT levels were found to be lower in the SAT group (p < 0.001). DS/NT and DS/TT levels were significantly higher in the patients with SAT, whereas NT/TT levels were lower (p < 0.05). A negative correlation was detected between C-reactive protein (CRP) and TAS, whereas a positive correlation was detected between CRP and OSI. There was a negative association between TSH and TAS only in the partial correlation analysis by adjusting for age, white blood cell count, neutrophil (Neu) level, CRP, and erythrocyte sedimentation rate (ESR) (r = –0.481, p = 0.043).

Conclusions: Thiol levels are significantly decreased and thiol/disulphide homoeostasis is disrupted in patients with SAT. The present study has presented for the first time that there may be an association between SAT and oxidative stress.

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Keywords

subacute thyroiditis; pathogenesis; oxidative stress; inflammation; dynamic thiol/disulphide

About this article
Title

Is oxidative stress a factor in the pathogenesis of subacute thyroiditis?

Journal

Endokrynologia Polska

Issue

Vol 73, No 1 (2022)

Article type

Original paper

Pages

64-70

Published online

2022-02-08

Page views

5540

Article views/downloads

616

DOI

10.5603/EP.a2021.0105

Pubmed

35156704

Bibliographic record

Endokrynol Pol 2022;73(1):64-70.

Keywords

subacute thyroiditis
pathogenesis
oxidative stress
inflammation
dynamic thiol/disulphide

Authors

Murat Dağdeviren
Arzu Or Koca
Tolga Akkan
Salim Neşelioğlu
Özcan Erel
Mustafa Altay

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