open access

Vol 71, No 5 (2020)
Review paper
Published online: 2020-10-30
Submitted: 2020-05-25
Accepted: 2020-06-27
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An overview of biological research on hypoxia-inducible factors (HIFs)

Zhe Liu, Zixuan Wu, Yuxin Fan, Yudong Fang
DOI: 10.5603/EP.a2020.0064
·
Pubmed: 33202030
·
Endokrynologia Polska 2020;71(5):432-440.

open access

Vol 71, No 5 (2020)
Review Article
Published online: 2020-10-30
Submitted: 2020-05-25
Accepted: 2020-06-27

Abstract

Hypoxia-inducible factors (HIFs), as a family of transcription factors involved in the cellular response to hypoxia, are key regulatory factors in the regulation mechanism of an organism’s response to hypoxia. A large number of studies have shown that HIFs are closely related to the angiogenesis, erythropoiesis, cell metabolism, and autophagy of organisms, as well as the occurrence and development of tumours. Therefore, it is of great significance to further study HIFs to understand and treat tumours or other related diseases. This paper summarises the structure, oxygen-dependent degradation mechanism, non-oxygen-dependent degradation mechanism, transcriptional activation mechanism, relevant signalling pathways, and inhibitors of HIFs, in order to provide new clues for the treatment of tumour, vascular, and other related diseases. 

Abstract

Hypoxia-inducible factors (HIFs), as a family of transcription factors involved in the cellular response to hypoxia, are key regulatory factors in the regulation mechanism of an organism’s response to hypoxia. A large number of studies have shown that HIFs are closely related to the angiogenesis, erythropoiesis, cell metabolism, and autophagy of organisms, as well as the occurrence and development of tumours. Therefore, it is of great significance to further study HIFs to understand and treat tumours or other related diseases. This paper summarises the structure, oxygen-dependent degradation mechanism, non-oxygen-dependent degradation mechanism, transcriptional activation mechanism, relevant signalling pathways, and inhibitors of HIFs, in order to provide new clues for the treatment of tumour, vascular, and other related diseases. 

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Keywords

HIFs; biological research

About this article
Title

An overview of biological research on hypoxia-inducible factors (HIFs)

Journal

Endokrynologia Polska

Issue

Vol 71, No 5 (2020)

Article type

Review paper

Pages

432-440

Published online

2020-10-30

DOI

10.5603/EP.a2020.0064

Pubmed

33202030

Bibliographic record

Endokrynologia Polska 2020;71(5):432-440.

Keywords

HIFs
biological research

Authors

Zhe Liu
Zixuan Wu
Yuxin Fan
Yudong Fang

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