open access

Vol 58, No 4 (2007)
Review article
Published online: 2007-05-17
Submitted: 2013-02-15
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Discovery and uses of pegvisomant: a growth hormone antagonist

Darlene E. Berryman, Amanda J. Palmer, Elahu S. Gosney, Svetha Swaminathan, Dave DeSantis, John J. Kopchick
Endokrynologia Polska 2007;58(4):322-329.

open access

Vol 58, No 4 (2007)
Review article
Published online: 2007-05-17
Submitted: 2013-02-15

Abstract

Growth hormone (GH) is a well established participant in several complex physiological processes including growth, differentiation, and metabolism. Recombinant human GH is a drug that has been approved for use for several clinical conditions where the action of GH is diminished or completely lacking. Thus there is considerable interest in developing novel drugs that modify the function of GH. Only in the last several decades have the detailed structural features of GH along with its interaction with its receptor been elucidated. In this review we summarise the basic structural and functional properties of GH, its receptor and their interaction. In addition, we discuss the discovery and development of an effective GH receptor antagonist, pegvisomant, and summarise potential therapeutic uses of this drug.
(Pol J Endocrinol 2007; 58 (4): 322-329)

Abstract

Growth hormone (GH) is a well established participant in several complex physiological processes including growth, differentiation, and metabolism. Recombinant human GH is a drug that has been approved for use for several clinical conditions where the action of GH is diminished or completely lacking. Thus there is considerable interest in developing novel drugs that modify the function of GH. Only in the last several decades have the detailed structural features of GH along with its interaction with its receptor been elucidated. In this review we summarise the basic structural and functional properties of GH, its receptor and their interaction. In addition, we discuss the discovery and development of an effective GH receptor antagonist, pegvisomant, and summarise potential therapeutic uses of this drug.
(Pol J Endocrinol 2007; 58 (4): 322-329)
Get Citation

Keywords

growth hormone; growth hormone receptor; growth hormone receptor antagonist

About this article
Title

Discovery and uses of pegvisomant: a growth hormone antagonist

Journal

Endokrynologia Polska

Issue

Vol 58, No 4 (2007)

Pages

322-329

Published online

2007-05-17

Bibliographic record

Endokrynologia Polska 2007;58(4):322-329.

Keywords

growth hormone
growth hormone receptor
growth hormone receptor antagonist

Authors

Darlene E. Berryman
Amanda J. Palmer
Elahu S. Gosney
Svetha Swaminathan
Dave DeSantis
John J. Kopchick

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