Vol 58, No 4 (2007)
Review paper
Published online: 2007-05-17
Discovery and uses of pegvisomant: a growth hormone antagonist
Endokrynol Pol 2007;58(4):322-329.
Abstract
Growth hormone (GH) is a well established participant in several complex physiological processes including growth, differentiation,
and metabolism. Recombinant human GH is a drug that has been approved for use for several clinical conditions
where the action of GH is diminished or completely lacking. Thus there is considerable interest in developing novel
drugs that modify the function of GH. Only in the last several decades have the detailed structural features of GH along
with its interaction with its receptor been elucidated. In this review we summarise the basic structural and functional
properties of GH, its receptor and their interaction. In addition, we discuss the discovery and development of an effective
GH receptor antagonist, pegvisomant, and summarise potential therapeutic uses of this drug.
(Pol J Endocrinol 2007; 58 (4): 322-329)
(Pol J Endocrinol 2007; 58 (4): 322-329)
Keywords: growth hormonegrowth hormone receptorgrowth hormone receptor antagonist