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Pulmonary involvement in lassa fever: a scoping review
, 3, 4, 5
Affiliations- Department of Internal Medicine, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA
- Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria
- Department of Respiratory Medicine, St Mary Hospital, Newport, Isle of Wight, United Kingdom
- Department of Medicine, Federal Medical Centre, Owo, Ondo State, Nigeria
- Department of Public Health, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA
open access
Abstract
INTRODUCTION: Lassa fever (LF) affects all body systems, however, inadequate knowledge exists on the involvement of the pulmonary system in LF infections. This scoping review, therefore, aimed to describe the pulmonary involvement of LF.
MATERIAL AND METHODS: We conducted an extensive search of the literature on two databases, namely PubMed and Google Scholar. Overall, 5,217 articles were retrieved from a database search, out of which 107 duplicates were removed. Overall, 12 articles were included: four review articles, three case reports, three experimental inoculation studies, one retrospective study, and a prospective case-control study.
RESULTS: Symptoms experienced included fever, pharyngitis, retrosternal pain, respiratory distress, and proteinuria. Complications included unique pulmonary arteritis, pulmonary embolization, mucosal bleeding, pleural or pericardial effusion, pulmonary edema, and interstitial pneumonitis. Consequences of the effect of Lassa virus infection were impairment of the immune system alongside continual replication of Lassa virus infection in affected tissues and death of affected individuals. LF has varied but serious effects on the pulmonary system.
CONCLUSIONS: These symptoms, particularly in areas where LF is known to be endemic, should prompt clinicians to request LF polymerase chain reaction for confirmatory diagnosis. These features should promote the provision of respiratory support for patients in need of such.
Abstract
INTRODUCTION: Lassa fever (LF) affects all body systems, however, inadequate knowledge exists on the involvement of the pulmonary system in LF infections. This scoping review, therefore, aimed to describe the pulmonary involvement of LF.
MATERIAL AND METHODS: We conducted an extensive search of the literature on two databases, namely PubMed and Google Scholar. Overall, 5,217 articles were retrieved from a database search, out of which 107 duplicates were removed. Overall, 12 articles were included: four review articles, three case reports, three experimental inoculation studies, one retrospective study, and a prospective case-control study.
RESULTS: Symptoms experienced included fever, pharyngitis, retrosternal pain, respiratory distress, and proteinuria. Complications included unique pulmonary arteritis, pulmonary embolization, mucosal bleeding, pleural or pericardial effusion, pulmonary edema, and interstitial pneumonitis. Consequences of the effect of Lassa virus infection were impairment of the immune system alongside continual replication of Lassa virus infection in affected tissues and death of affected individuals. LF has varied but serious effects on the pulmonary system.
CONCLUSIONS: These symptoms, particularly in areas where LF is known to be endemic, should prompt clinicians to request LF polymerase chain reaction for confirmatory diagnosis. These features should promote the provision of respiratory support for patients in need of such.
Keywords
Lassa hemorrhagic fever; lungs; Mastomys natalensis; pulmonary involvement in Lassa fever; Lassa virus
About this articleTitle
Pulmonary involvement in lassa fever: a scoping review
Journal
Disaster and Emergency Medicine Journal
Issue
Article type
Research paper
Pages
97-109
Published online
2023-02-22
Page views
1237
Article views/downloads
344
DOI
Bibliographic record
Disaster Emerg Med J 2023;8(2):97-109.
Keywords
Lassa hemorrhagic fever
lungs
Mastomys natalensis
pulmonary involvement in Lassa fever
Lassa virus
Authors
Olayinka S. Ilesanmi
Aanuoluwapo A. Afolabi
Bamidele O. Adeniyi
Bosede Amodu
Chukwudi S. Ubah
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