open access

Vol 6, No 3 (2021)
Research paper
Published online: 2021-07-20
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Effect of rocuronium on the heart rate and arterial blood pressure during combined general anaesthesia

Urszula Kosciuczuk1, Paulina Gluszynska2, Inna Diemieszczyk2, Aleksander Lukaszewicz2, Krzysztof Bauer3, Maciej Kokoszko4, Lukasz Szarpak5, Jerzy Robert Ladny3, Hady Razak Hady2
·
Disaster Emerg Med J 2021;6(3):104-111.
Affiliations
  1. Department of Anaesthesiology and Intensive Therapy, Medical University of Bialystok, Poland
  2. 1st Department of General Surgery and Endocrine Surgery, Medical University of Bialystok, Poland
  3. Department of Emergency Medicine and Disaster, Medical University of Bialystok, Poland
  4. Cancer Treatment Centre in Bialystok, Bialystok, Poland
  5. Institute of Outcomes Research, Maria Sklodowska-Curie Medical Academy, Warsaw, Poland

open access

Vol 6, No 3 (2021)
ORIGINAL ARTICLES
Published online: 2021-07-20

Abstract

INTRODUCTION: Additional mechanisms of neuromuscular blocking agents action create the haemodynamic condition during general anaesthesia. The aim was to investigate the effect of rocuronium on haemodynamic parameters during combined general anaesthesia.  

MATERIAL AND METHODS: The study was conducted in two groups: Group I underwent combined anaesthesia with rocuronium and Group II — combined anaesthesia without any muscle relaxants. Haemodynamic parameters: heart rate, systolic, diastolic and mean arterial blood pressure were recorded before anaesthesia, at the end of rocuronium infusion, and after recovery from anaesthesia.  

RESULTS: In both groups, the values of the median heart rate, systolic, diastolic and mean arterial blood pressure recorded before and after anaesthesia were similar and did not differ significantly. In Group I, significant reduction in heart rate in the end of rocuronium infusion [74 (61–103)], (p = 0.01) and after recovery from anesthesia [71 (53–100)], (p = 0.03), compared to the value before anesthesia [81 (56–104)], were demonstrated. Additionally, significant reduction in systolic [130 (96–169); 114 (92–144)], (p = 0.04), diastolic [80 (54–109); 73 (47–99)], (p = 0.01), and mean [95 (72–106); 85 (68–109)], (p = 0.02) arterial blood pressure in the end of rocuronium infusion were noticed. The values of systolic, diastolic and mean blood pressure after recovery from anaesthesia significantly increased in relation to the values observed in the end of the rocuronium infusion [129 (96–181)], (p = 0.01); [78 (47–107)], (p = 0.03); [93 (63–107)], (p = 0.03).  

CONCLUSIONS: The vagolytic effect was not observed during general anaesthesia with rocuronium. The changes in heart rate and blood pressure were associated with the rocuronium infusion and were normalized after recovery from anaesthesia.

Abstract

INTRODUCTION: Additional mechanisms of neuromuscular blocking agents action create the haemodynamic condition during general anaesthesia. The aim was to investigate the effect of rocuronium on haemodynamic parameters during combined general anaesthesia.  

MATERIAL AND METHODS: The study was conducted in two groups: Group I underwent combined anaesthesia with rocuronium and Group II — combined anaesthesia without any muscle relaxants. Haemodynamic parameters: heart rate, systolic, diastolic and mean arterial blood pressure were recorded before anaesthesia, at the end of rocuronium infusion, and after recovery from anaesthesia.  

RESULTS: In both groups, the values of the median heart rate, systolic, diastolic and mean arterial blood pressure recorded before and after anaesthesia were similar and did not differ significantly. In Group I, significant reduction in heart rate in the end of rocuronium infusion [74 (61–103)], (p = 0.01) and after recovery from anesthesia [71 (53–100)], (p = 0.03), compared to the value before anesthesia [81 (56–104)], were demonstrated. Additionally, significant reduction in systolic [130 (96–169); 114 (92–144)], (p = 0.04), diastolic [80 (54–109); 73 (47–99)], (p = 0.01), and mean [95 (72–106); 85 (68–109)], (p = 0.02) arterial blood pressure in the end of rocuronium infusion were noticed. The values of systolic, diastolic and mean blood pressure after recovery from anaesthesia significantly increased in relation to the values observed in the end of the rocuronium infusion [129 (96–181)], (p = 0.01); [78 (47–107)], (p = 0.03); [93 (63–107)], (p = 0.03).  

CONCLUSIONS: The vagolytic effect was not observed during general anaesthesia with rocuronium. The changes in heart rate and blood pressure were associated with the rocuronium infusion and were normalized after recovery from anaesthesia.

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Keywords

anaesthesiology, haemodynamic state, neuromuscular blocking agents

About this article
Title

Effect of rocuronium on the heart rate and arterial blood pressure during combined general anaesthesia

Journal

Disaster and Emergency Medicine Journal

Issue

Vol 6, No 3 (2021)

Article type

Research paper

Pages

104-111

Published online

2021-07-20

Page views

8208

Article views/downloads

1022

DOI

10.5603/DEMJ.a2021.0020

Bibliographic record

Disaster Emerg Med J 2021;6(3):104-111.

Keywords

anaesthesiology
haemodynamic state
neuromuscular blocking agents

Authors

Urszula Kosciuczuk
Paulina Gluszynska
Inna Diemieszczyk
Aleksander Lukaszewicz
Krzysztof Bauer
Maciej Kokoszko
Lukasz Szarpak
Jerzy Robert Ladny
Hady Razak Hady

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