open access

Vol 6, No 2 (2021)
Review paper
Published online: 2021-06-28
Get Citation

Place of tranexamic acid in modern medicine

Mahdi Al-Jeabory12, Jaroslaw Pecold3, Aleksandra Gasecka4, Lukasz Szarpak56, Wladyslaw Gawel7, Nataliia Litvinova8
DOI: 10.5603/DEMJ.a2021.0015
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Disaster Emerg Med J 2021;6(2):85-89.
Affiliations
  1. Institute of Outcomes Research, Polonia University, Czestochowa, Poland
  2. Polish Society of Disaster Medicine, Warsaw, Poland
  3. Department of Trauma and Orthopedic Surgery, Ruda Slaska City Hospital, Ruda Slaska, Poland
  4. 1st Chair and Department of Cardiology, Medical University of Warsaw, Poland
  5. Maria Sklodowska-Curie Medical Academy in Warsaw, Poland
  6. Maria Sklodowska-Curie Bialystok Oncology Center, Bialystok, Poland
  7. Department of Surgery, The Silesian Hospital in Opava, Czech Republic
  8. European Medical School, International European University, Kiev, Ukraine

open access

Vol 6, No 2 (2021)
REVIEW ARTICLES
Published online: 2021-06-28

Abstract

Massive bleedings, both internal and external, are among the leading causes of preventable deaths. The research for the appropriate treatment focuses not only on looking for the new drugs but also relies on finding the new indications for the drugs already known in the pharmacotherapy of different disease. However, such an approach requires new protocols in order to be effective. One of the substances in question is tranexamic acid, which uses due to its antifibrinolytic effect is raising both in prehospital and hospital settings.

Abstract

Massive bleedings, both internal and external, are among the leading causes of preventable deaths. The research for the appropriate treatment focuses not only on looking for the new drugs but also relies on finding the new indications for the drugs already known in the pharmacotherapy of different disease. However, such an approach requires new protocols in order to be effective. One of the substances in question is tranexamic acid, which uses due to its antifibrinolytic effect is raising both in prehospital and hospital settings.

Get Citation

Keywords

tranexamic acid, TXA, trauma, bleeding, hemorrhage

About this article
Title

Place of tranexamic acid in modern medicine

Journal

Disaster and Emergency Medicine Journal

Issue

Vol 6, No 2 (2021)

Article type

Review paper

Pages

85-89

Published online

2021-06-28

DOI

10.5603/DEMJ.a2021.0015

Bibliographic record

Disaster Emerg Med J 2021;6(2):85-89.

Keywords

tranexamic acid
TXA
trauma
bleeding
hemorrhage

Authors

Mahdi Al-Jeabory
Jaroslaw Pecold
Aleksandra Gasecka
Lukasz Szarpak
Wladyslaw Gawel
Nataliia Litvinova

References (38)
  1. Hunt BJ. The current place of tranexamic acid in the management of bleeding. Anaesthesia. 2015; 70 Suppl 1: 50–3, e18.
  2. Moore EE, Moore HB, Kornblith LZ, et al. Subcommittees on Fibrinolysis, Disseminated Intravascular Coagulation, and Perioperative and Critical Care Thrombosis and Hemostasis, TACTIC Investigators. Trauma-Induced Coagulopathy: An Institution's 35 Year Perspective on Practice and Research. Scand J Surg. 2014; 103(2): 89–103.
  3. Stansfield R, Morris D, Jesulola E. The Use of Tranexamic Acid (TXA) for the Management of Hemorrhage in Trauma Patients in the Prehospital Environment: Literature Review and Descriptive Analysis of Principal Themes. Shock. 2020; 53(3): 277–283.
  4. Al-Jeabory M, Szarpak L, Attila K, et al. Efficacy and Safety of Tranexamic Acid in Emergency Trauma: A Systematic Review and Meta-Analysis. J Clin Med. 2021; 10(5).
  5. Matthay ZA, Hellmann ZJ, Callcut RA, et al. Outcomes after ultramassive transfusion in the modern era: An Eastern Association for the Surgery of Trauma multicenter study. J Trauma Acute Care Surg. 2021; 91(1): 24–33.
  6. Zhao WJ, Liu GE, Tian Y, et al. What's new in trauma 2020. Chin J Traumatol. 2021; 24(2): 63–68.
  7. Khanna VA, Chidambaram S, Goh EnL. Prehospital Advanced Life Support for Out-of-Hospital Cardiac Arrest in Blunt Trauma Patients. JAMA Surg. 2019; 154(1): 95–96.
  8. Brambrink AM, Koerner IP. Prehospital advanced trauma life support: how should we manage the airway, and who should do it? Crit Care. 2004; 8(1): 3–5.
  9. Johnson WD, Griswold DP. Traumatic brain injury: a global challenge. Lancet Neurol. 2017; 16(12): 949–950.
  10. LaPelusa A, Dave HD. Physiology, Hemostasis. Treasure Island (FL): StatPearls Publishing. ; 2021.
  11. Martini WZ. Coagulation complications following trauma. Mil Med Res. 2016; 3: 35.
  12. WOLFSON LJ. BLOOD LOSS IN TRAUMA. Ann R Coll Surg Engl. 1963; 33: 158–164.
  13. Neeki MM, Dong F, Toy J, et al. Efficacy and Safety of Tranexamic Acid in Prehospital Traumatic Hemorrhagic Shock: Outcomes of the Cal-PAT Study. West J Emerg Med. 2017; 18(4): 673–683.
  14. Frith D, Goslings JC, Gaarder C, et al. Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations. J Thromb Haemost. 2010; 8(9): 1919–1925.
  15. McCormack PL. Tranexamic acid: a review of its use in the treatment of hyperfibrinolysis. Drugs. 2012; 72(5): 585–617.
  16. Dirkmann D, Görlinger K, Gisbertz C, et al. Factor XIII and tranexamic acid but not recombinant factor VIIa attenuate tissue plasminogen activator-induced hyperfibrinolysis in human whole blood. Anesth Analg. 2012; 114(6): 1182–1188.
  17. Cho MJ, Rohrich RJ, Rohrich RJ, et al. The Role of Tranexamic Acid in Plastic Surgery: Review and Technical Considerations. Plast Reconstr Surg. 2018; 141(2): 507–515.
  18. Myles PS, Smith JA, Kasza J, et al. ATACAS investigators and the ANZCA Clinical Trials Network, ATACAS investigators and the ANZCA Clinical Trials Network, ATACAS Investigators of the ANZCA Clinical Trials Network, ATACAS Investigators of the ANZCA Clinical Trials Network. Stopping vs. Continuing Aspirin before Coronary Artery Surgery. N Engl J Med. 2016; 374(8): 728–737.
  19. Monaco F, Nardelli P, Pasin L, et al. Tranexamic acid in open aortic aneurysm surgery: a randomised clinical trial. Br J Anaesth. 2020; 124(1): 35–43.
  20. Ker K, Roberts I, Shakur H, et al. CRASH-2 Trial collaborators, CRASH-2 Trial collaborators. Antifibrinolytic drugs for acute traumatic injury. Cochrane Database Syst Rev. 2011; 12(1): CD004896.
  21. Zehtabchi S, Abdel Baki SG, Falzon L, et al. Tranexamic acid for traumatic brain injury: a systematic review and meta-analysis. Am J Emerg Med. 2014; 32(12): 1503–1509.
  22. Fillingham YA, Ramkumar DB, Jevsevar DS, et al. The Efficacy of Tranexamic Acid in Total Knee Arthroplasty: A Network Meta-Analysis. J Arthroplasty. 2018; 33(10): 3090–3098.e1.
  23. Kirsch JM, Bedi A, Horner N, et al. Tranexamic Acid in Shoulder Arthroplasty: A Systematic Review and Meta-Analysis. JBJS Rev. 2017; 5(9): e3.
  24. Ahmadzia HK, Luban NLC, Li S, et al. Optimal use of intravenous tranexamic acid for hemorrhage prevention in pregnant women. Am J Obstet Gynecol. 2020 [Epub ahead of print].
  25. Franchini M, Mengoli C, Cruciani M, et al. Safety and efficacy of tranexamic acid for prevention of obstetric haemorrhage: an updated systematic review and meta-analysis. Blood Transfus. 2018; 16(4): 329–337.
  26. Bhat A, Bhowmik DM, Vibha D, et al. Tranexamic acid overdosage-induced generalized seizure in renal failure. Saudi J Kidney Dis Transpl. 2014; 25(1): 130–132.
  27. Takagi H, Ando T, Umemoto T, et al. All-Literature Investigation of Cardiovascular Evidence (ALICE) group. Seizures associated with tranexamic acid for cardiac surgery: a meta-analysis of randomized and non-randomized studies. J Cardiovasc Surg (Torino). 2017; 58(4): 633–641.
  28. Manji RA, Grocott HP, Leake J, et al. Seizures following cardiac surgery: the impact of tranexamic acid and other risk factors. Can J Anaesth. 2012; 59(1): 6–13.
  29. Hales TG, Lambert JJ. The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones. Br J Pharmacol. 1991; 104(3): 619–628.
  30. Donovan RL, Varma JR, Whitehouse MR, et al. Tranexamic acid use to decrease blood loss in primary shoulder and elbow replacement: A systematic review and meta-analysis. J Orthop. 2021; 24: 239–247.
  31. Pabinger I, Fries D, Schöchl H, et al. Tranexamic acid for treatment and prophylaxis of bleeding and hyperfibrinolysis. Wien Klin Wochenschr. 2017; 129(9-10): 303–316.
  32. Pilbrant A, Schannong M, Vessman J, et al. Pharmacokinetics of tranexamic acid after intravenous administration to normal volunteers. Eur J Clin Pharmacol. 1974; 7(5): 375–380.
  33. Box HN, Tisano BS, Khazzam M. Tranexamic acid administration for anatomic and reverse total shoulder arthroplasty: a systematic review and meta-analysis. JSES Open Access. 2018; 2(1): 28–33.
  34. Hartland AW, Teoh KH, Rashid MS. Clinical Effectiveness of Intraoperative Tranexamic Acid Use in Shoulder Surgery: A Systematic Review and Meta-analysis. Am J Sports Med. 2021 [Epub ahead of print]: 363546520981679.
  35. Roberts I, Shakur H, Coats T, et al. The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients. Health Technol Assess. 2013; 17(10): 1–79.
  36. Morte D, Lammers D, Bingham J, et al. Tranexamic acid administration following head trauma in a combat setting: Does tranexamic acid result in improved neurologic outcomes? J Trauma Acute Care Surg. 2019; 87(1): 125–129.
  37. Montgomery HR, Drew B. Tactical Combat Casualty Care (TCCC) Update. J Spec Oper Med. 2020; 20(2): 152–153.
  38. Bennett BL, Butler FK, Wedmore IS. Tactical Combat Casualty Care: Transitioning Battlefield Lessons Learned to Other Austere Environments. Wilderness Environ Med. 2017; 28(2S): S3–S4.

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