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Immune system correlation dynamics in ultra-rush wasp venom immunotherapy
Affiliations- Institute of Outcomes Research, Maria Sklodowska-Curie Medical Academy, Warsaw, Poland
- Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Magdalenka, Poland
- Department of Infectious Diseases and Allergology, Military Institute of Medicine, National Research Institute, Magdalenka, Poland
- Military Centre of Preventive Medicine, Nowy Dwór Mazowiecki, Poland
- Department of Regenerative Medicine, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland
- Faculty of Health Sciences, The Mazovian State University in Płock, Plock, Poland
- Department of Public Health, International European University, Kyiv, Ukraine
- Henry JN Taub Department of Emergency Medicine, Baylor College of Medicine Houston, Houston, TX, United States
- Department of Clinical Research and Development, LUXMED Group, Warsaw, Poland
open access
Abstract
INTRODUCTION: Venom Immunotherapy (VIT) stands as an effective approach for addressing Hymenoptera
venom allergies, yet the intricate journey of reprogramming the immune system’s hypersensitive response
to wasp venom allergens remains a frontier ready for exploration. Generally, VIT orchestrates a shift in the
polarization of Th2 and Th1 lymphocytes, fostering a greater prevalence of tolerogenic reactions mediated
by Treg lymphocytes and dendritic cells. This orchestrated shift precipitates a decline in the activity and abundance
of eosinophils, basophils, and mast cells — key effector cells in allergic reactions. These transformative
alterations stem from intricate cell-to-cell communication modulated by cytokines.
MATERIAL AND METHODS: In this investigation, correlated was data derived from the immune system analysis
of individuals with wasp venom allergy (Muller’s scale III and IV) undergoing VIT, drawing samples at intervals
of 0, 2, 6, and 24 weeks post-initial dose. These findings were compared with outcomes from a control group
experiencing mild inflammatory reactions post-wasp sting. The authors’ scrutiny encompassed 50 diverse immune
system components, spanning white blood cell subpopulations, complement components (C3, C4, and
C5), concentrations of histamine and tryptase, and selected cytokine concentrations encompassing interleukins,
tumour necrosis factor-alpha, interferon-gamma, transforming growth factors beta, chemokines, growth
factors, and the IL-1 receptor antagonist. Through meticulous analysis, the present extensive dataset was categorized
into distinct groups based on the effects elicited by VIT: immediate, delayed, late effect, and temporary.
RESULTS: Our findings unveiled compelling correlations in various VIT response types, particularly linked to
IL4, IL7, IL12, IL15, IL17, and CCL3.
CONCLUSIONS: These observed shifts underscore the pivotal roles individual cytokines and their interactions
play in the desensitization process induced by VIT treatment. However, a comprehensive understanding of
this intricate process warrants further in-depth investigation.
Abstract
INTRODUCTION: Venom Immunotherapy (VIT) stands as an effective approach for addressing Hymenoptera
venom allergies, yet the intricate journey of reprogramming the immune system’s hypersensitive response
to wasp venom allergens remains a frontier ready for exploration. Generally, VIT orchestrates a shift in the
polarization of Th2 and Th1 lymphocytes, fostering a greater prevalence of tolerogenic reactions mediated
by Treg lymphocytes and dendritic cells. This orchestrated shift precipitates a decline in the activity and abundance
of eosinophils, basophils, and mast cells — key effector cells in allergic reactions. These transformative
alterations stem from intricate cell-to-cell communication modulated by cytokines.
MATERIAL AND METHODS: In this investigation, correlated was data derived from the immune system analysis
of individuals with wasp venom allergy (Muller’s scale III and IV) undergoing VIT, drawing samples at intervals
of 0, 2, 6, and 24 weeks post-initial dose. These findings were compared with outcomes from a control group
experiencing mild inflammatory reactions post-wasp sting. The authors’ scrutiny encompassed 50 diverse immune
system components, spanning white blood cell subpopulations, complement components (C3, C4, and
C5), concentrations of histamine and tryptase, and selected cytokine concentrations encompassing interleukins,
tumour necrosis factor-alpha, interferon-gamma, transforming growth factors beta, chemokines, growth
factors, and the IL-1 receptor antagonist. Through meticulous analysis, the present extensive dataset was categorized
into distinct groups based on the effects elicited by VIT: immediate, delayed, late effect, and temporary.
RESULTS: Our findings unveiled compelling correlations in various VIT response types, particularly linked to
IL4, IL7, IL12, IL15, IL17, and CCL3.
CONCLUSIONS: These observed shifts underscore the pivotal roles individual cytokines and their interactions
play in the desensitization process induced by VIT treatment. However, a comprehensive understanding of
this intricate process warrants further in-depth investigation.
Keywords
desensitization; wasp venom; VIT; immune system; immunotherapy; allergy
About this articleTitle
Immune system correlation dynamics in ultra-rush wasp venom immunotherapy
Journal
Disaster and Emergency Medicine Journal
Issue
Article type
Research paper
Pages
243-254
Published online
2023-12-13
Page views
385
Article views/downloads
132
DOI
Bibliographic record
Disaster Emerg Med J 2023;8(4):243-254.
Keywords
desensitization
wasp venom
VIT
immune system
immunotherapy
allergy
Authors
Slawomir Lewicki
Lukasz Szymanski
Weronika Urbanska
Aneta Lewicka
Martyna Ciepielak
Wanda Stankiewicz
Malgorzata Palusinska
Michal Pruc
Lukasz Szarpak
Andrzej Chcialowski
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