open access

Vol 5, No 3 (2020)
Letter to the Editor
Published online: 2020-06-15
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Interferon lambda with remdesivir as a potential treatment option in COVID-19

Ishag Adam, Lukasz Szarpak, Krzysztof Jerzy Filipiak, Jacek Smereka, Marek Dabrowski, Saeid Ghavami, Milosz Jaguszewski
DOI: 10.5603/DEMJ.a2020.0027
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Disaster Emerg Med J 2020;5(3):174.

open access

Vol 5, No 3 (2020)
LETTERS TO THE EDITOR
Published online: 2020-06-15

Abstract

Not available

Abstract

Not available
Get Citation

Keywords

remdesivir, interferon lambda, COVID-19, SARS-CoV-2, treatment

About this article
Title

Interferon lambda with remdesivir as a potential treatment option in COVID-19

Journal

Disaster and Emergency Medicine Journal

Issue

Vol 5, No 3 (2020)

Article type

Letter to the Editor

Pages

174

Published online

2020-06-15

DOI

10.5603/DEMJ.a2020.0027

Bibliographic record

Disaster Emerg Med J 2020;5(3):174.

Keywords

remdesivir
interferon lambda
COVID-19
SARS-CoV-2
treatment

Authors

Ishag Adam
Lukasz Szarpak
Krzysztof Jerzy Filipiak
Jacek Smereka
Marek Dabrowski
Saeid Ghavami
Milosz Jaguszewski

References (5)
  1. Grein J, Ohmagari N, Shin D, et al. Compassionate Use of Remdesivir for Patients with Severe Covid-19. N Engl J Med. 2020 [Epub ahead of print].
  2. Malik YS, Sircar S, Bhat S, et al. Emerging novel coronavirus (2019-nCoV)-current scenario, evolutionary perspective based on genome analysis and recent developments. Vet Q. 2020; 40(1): 68–76.
  3. Gordon CJ, Tchesnokov EP, Woolner E, et al. Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency. J Biol Chem. 2020; 295(20): 6785–6797.
  4. Hemann EA, Schwerk J, Savan R. IFN-λ 'guts' neutrophil-mediated inflammation. Nat Immunol. 2017; 18(10): 1061–1062.
  5. Mordstein M, Neugebauer E, Ditt V, et al. Lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections. J Virol. 2010; 84(11): 5670–5677.

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