Online first
Research paper
Published online: 2025-01-17

open access

Page views 183
Article views/downloads 74
Get Citation

Connect on Social Media

Connect on Social Media

Predictive factors of chronic obstructive pulmonary disease on emergency ward visits

Aynur Yurtseven1, Yasemin Yılmaz Aydın2, Kerem Ensarioğlu2, Bahar Kurt1

Abstract

INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is one of the most prominent diseases in pulmonology due to its high incidence, preventable nature, and in cases where exposure to irritants had continued, an increased overall morbidity and mortality. This study was performed to evaluate if local risk factors exist for COPD patients that affect emergency ward visits and to investigate if enough data may be gathered to create a model for risk assessment.

MATERIAL AND METHODS: The study was conducted as a retrospective, single-center cohort in a tertiary training and research hospital. The study evaluated patients between January 1, 2015, and January 31, 2020, with the collaboration of the Emergency Medicine and Pulmonary Medicine departments. Patients who had a confirmed COPD diagnosis, an emergency admission, and a pulmonary medicine consultation were included in the study, while those leaving against medical advice, transferred to other departments, and with incomplete consultation notes were excluded. The patient’s demographic data, symptom presence, known comorbidities, drug history, medical treatment given in the emergency ward, respiratory risk factors, auscultation findings, vitals at admission, routine laboratory results, and radiological findings were recorded. Descriptive statistics were used to summarize data, presented as means with standard deviations or medians with percentiles as appropriate. Parametric distribution was assessed via quantile–quantile (Q–Q) plots. Significant variables were tested by binomial regression analysis.

RESULTS: A total of 306 patients were evaluated. Change in phlegm and chest pain were the symptoms positively correlated with repeated emergency admission. Hypertension, coronary heart disease, and arrhythmia were the comorbidities with a correlation. Treatment-wise, bilevel pressure support device requirement, lipid-lowering regimen, and anticoagulant use were found to correlate with repeated emergency ward admission. The regression model showed that chest pain, hypertension, coronary arterial disease, arrhythmia, anti-lipid regimen requirement, desaturation at admission, presence of infection in imaging modalities, and hospital admission within a week were independent predictive factors for repeated emergency ward admission.

CONCLUSIONS: Cardiac-related symptoms and treatment history, desaturation, presence of pulmonary infection, and former hospital admission history are independent risk factors affecting repeated emergency ward admission for COPD patients. These observations correlate with the available literature, especially in terms of the correlation between repeated admission and cardiac comorbidities.

Article available in PDF format

View PDF Download PDF file

References

  1. Doiron D, de Hoogh K, Probst-Hensch N, et al. Air pollution, lung function and COPD: results from the population-based UK Biobank study. Eur Respir J. 2019; 54(1).
  2. Syamlal G, Kurth LM, Dodd KE, et al. Chronic obstructive pulmonary disease mortality by industry and occupation — United States, 2020. MMWR Morb Mortal Wkly Rep. 2022; 71(49): 1550–1554.
  3. Agustí A, Celli BR, Criner GJ, et al. Global initiative for chronic obstructive lung disease 2023 report: GOLD executive summary. Am J Respir Crit Care Med. 2023; 207(7): 819–837.
  4. Kupiainen H, Kinnula VL, Lindqvist A, et al. Successful smoking cessation in COPD: association with comorbidities and mortality. Pulm Med. 2012; 2012: 725024.
  5. Boutros P, Kassem N, Boudo V, et al. Understanding the risk factors, burden, and interventions for chronic respiratory diseases in low- and middle-income countries: a scoping review. Public Health Rev. 2024; 45: 1607339.
  6. May SM, Li JTC. Burden of chronic obstructive pulmonary disease: healthcare costs and beyond. Allergy Asthma Proc. 2015; 36(1): 4–10.
  7. Fermont JM, Bolton CE, Fisk M, et al. Risk assessment for hospital admission in patients with COPD; a multi-centre UK prospective observational study. PLoS One. 2020; 15(2): e0228940.
  8. Dalal AA, Shah M, D'Souza AO, et al. Costs of COPD exacerbations in the emergency department and inpatient setting. Respir Med. 2011; 105(3): 454–460.
  9. Madani NA, Carpenter DO. Patterns of emergency room visits for respiratory diseases in new york state in relation to air pollution, poverty and smoking. Int J Environ Res Public Health. 2023; 20(4): 3267.
  10. Gershon A, Thiruchelvam D, Moineddin R, et al. Forecasting hospitalization and emergency department visit rates for chronic obstructive pulmonary disease. A time-series analysis. Ann Am Thorac Soc. 2017; 14(6): 867–873.
  11. Leung C, Bourbeau J, Sin DD, et al. The prevalence of chronic obstructive pulmonary disease (COPD) and the heterogeneity of risk factors in the canadian population: results from the canadian obstructive lung disease (COLD) study. Int J Chron Obstruct Pulmon Dis. 2021; 16: 305–320.
  12. Montserrat-Capdevila J, Godoy P, Marsal JR, et al. Predictive model of hospital admission for COPD exacerbation. Respir Care. 2015; 60(9): 1288–1294.
  13. García-Sanz MT, Pol-Balado C, Abellás C, et al. Factors associated with hospital admission in patients reaching the emergency department with COPD exacerbation. Multidiscip Respir Med. 2012; 7(1): 6.
  14. Ruan H, Zhang H, Wang J, et al. Readmission rate for acute exacerbation of chronic obstructive pulmonary disease: a systematic review and meta-analysis. Respir Med. 2023; 206: 107090.
  15. Smith HL, Ellis CS. Evaluation of hospital admission status for emergency department patients seen for chronic obstructive pulmonary disease exacerbation: a retrospective observational study. Ochsner J. 2021; 21(1): 19–24.
  16. Baydar Toprak O, Polatli M, Baha A, et al. Readmission rates within the first 30 and 90 days after severe COPD exacerbations (RACE study). Medicine (Baltimore). 2024; 103(48): e40483.
  17. Alqahtani JS, Njoku CM, Bereznicki B, et al. Risk factors for all-cause hospital readmission following exacerbation of COPD: a systematic review and meta-analysis. Eur Respir Rev. 2020; 29(156): 190166.
  18. Soler JJ, Sánchez L, Román P, et al. Risk factors of emergency care and admissions in COPD patients with high consumption of health resources. Respir Med. 2004; 98(4): 318–329.
  19. Bottle A, Honeyford K, Chowdhury F, et al. Factors associated with hospital emergency readmission and mortality rates in patients with heart failure or chronic obstructive pulmonary disease: a national observational study. Health Serv Delivery Res. 2018; 6(26): 1–60.
  20. Waeijen-Smit K, Jacobsen PA, Houben-Wilke S, et al. All-cause admissions following a first ever exacerbation-related hospitalisation in COPD. ERJ Open Res. 2023; 9(1).
  21. Jo YS, Rhee CK, Kim KJ, et al. Risk factors for early readmission after acute exacerbation of chronic obstructive pulmonary disease. Ther Adv Respir Dis. 2020; 14: 1753466620961688.
  22. Lau AC, Yam LY, Poon E. Hospital re-admission in patients with acute exacerbation of chronic obstructive pulmonary disease. Respir Med. 2001; 95(11): 876–884.
  23. Pini L, Giordani J, Gardini G, et al. Emergency department admission and hospitalization for COPD exacerbation and particulate matter short-term exposure in Brescia, a highly polluted town in northern Italy. Respir Med. 2021; 179: 106334.