Tom 19, Nr 2 (2022)
Artykuł przeglądowy
Opublikowany online: 2022-09-20
Wyświetlenia strony
865
Wyświetlenia/pobrania artykułu
22
Inhibitory układu renina–angiotensyna–aldosteron — jak właściwie wybierać w 2022 roku?
1, 1
DOI: 10.5603/ChSiN.a2022.0005
Choroby Serca i Naczyń 2022;19(2):80-91.
Streszczenie
Inhibitory konwertazy angiotensyny (ACEI) oraz antagoniści receptora angiotensynowego (ARB) są grupami leków bardzo szeroko stosowanymi we współczesnej kardiologii i hipertensjologii. Mimo pozornych podobieństw leki te różnią się zasadniczo mechanizmem działania, co ma istotne znaczenie w praktyce klinicznej. W wielu wskazaniach preferowana opcja terapeutyczna to ACEI, w części sytuacji klinicznych obie grupy leków są w tej samej klasie zaleceń, natomiast nie ma obecnie wytycznych, w których postulowano by wyższość sartanów nad ACEI w leczeniu pierwszego rzutu. W nowej klasie leków, antagonistach receptora angiotensyny i inhibitorach neprilizyny, wykorzystuje się połączenie blokady receptora angiotensyny z blokadą neprilizyny. Wypadkowy efekt ich stosowania cechują duże podobieństwa do działania ACEI, dodatkowo wzbogacony o ochronę puli endogennych peptydów natriuretycznych.
Słowa kluczowe: inhibitory konwertazy angiotensyny (ACEI)antagoniści receptora angiotensynowego (ARB)sartanyukład renina–angiotensyna–aldosteron (RAAS)antagoniści receptora angiotensyny i inhibitory neprilizyny (ARNI)
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