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Tom 19, Nr 4 (2022)
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Opublikowany online: 2023-03-31

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Eksport do Mediów Społecznościowych

Eksport do Mediów Społecznościowych

Nadciśnienie tętnicze i jego leczenie a prewencja zaburzeń funkcji poznawczych — rola połączenia walsartanu i amlodipiny. Przegląd dla lekarza praktyka

Stanisław Surma1, Michał O. Zembala23
DOI: 10.5603/ChSiN.2022.0019
Choroby Serca i Naczyń 2022;19(4):160-177.

Streszczenie

Nadciśnienie tętnicze i demencja stanowią istotny problem współczesnej medycyny. Wśród wielu czynników ryzyka rozwoju zaburzeń funkcji poznawczych, szczególnie u osób w średnim wieku, znajduje się nadciśnienie tętnicze. Związek między nadciśnieniem tętniczym a zaburzeniami funkcji poznawczych jest złożony i nie ogranicza się jedynie do zwiększonego ciśnienia tętniczego, ale obejmuje także ciśnienie tętna, prędkość fali tętna, zmienność ciśnienia tętniczego oraz hipotonię ortostatyczną. Leki przeciwnadciśnieniowe są jedynymi znanymi lekami, które mogą zmniejszać ryzyko wystąpienia demencji. Szczególną rolę w prewencji zaburzeń funkcji poznawczych pełnią antagoniści wapnia (amlodipina) oraz sartany (walsartan). Leki te charakteryzują się korzystnym wpływem na wszystkie istotne w prewencji demencji czynniki związane z kontrolą ciśnienia tętniczego. Co więcej, są korzystne w prewencji udaru mózgu, który jest ważnym czynnikiem ryzyka demencji. Możliwość stosowania amlodipiny w połączeniu z walsartanem w postaci jednej tabletki dodatkowo zwiększa przestrzeganie zaleceń terapeutycznych, co przekłada się na lepszą kontrolę ciśnienia tętniczego i w konsekwencji na lepszą prewencję zaburzeń funkcji poznawczych. W niniejszym artykule podsumowano związek między nadciśnieniem tętniczym i jego leczeniem, ze szczególnym uwzględnieniem amlodipiny i walsartanu, a ryzykiem zaburzeń funkcji poznawczych.

Słowa kluczowe: nadciśnienie tętniczedemencjafunkcje poznawczewalsartanamlodipina

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