Tom 15, Nr 3 (2018)
Farmakoterapia chorób układu krążenia
Opublikowany online: 2018-12-11
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Wpływ terapii skojarzonej opartej na ezetimibie i statynie na metabolizm cholesterolu w świetle aktualnej wiedzy medycznej
Choroby Serca i Naczyń 2018;15(3):135-145.
Streszczenie
Artykuł stanowi próbę syntezy poglądów dotyczących fizjologii krążenia cholesterolu, a także roli zaburzeń lipidowych i ich wpływu na ryzyko sercowo-naczyniowe w różnych populacjach pacjentów. Jednocześnie w pracy opisano mechanizmy i sposoby terapeutycznej ingerencji w metabolizm lipoprotein osocza ze szczególnym uwzględnieniem w tym procesie skojarzonego wpływu statyn i ezetimibu. W ostatniej części artykułu zweryfikowano zasadność zastosowania powyższego schematu hipolipemizującego na podstawie dowodów uzyskanych w wieloośrodkowych randomizowanych badaniach klinicznych.
Słowa kluczowe: statyna i ezetimibterapia skojarzona
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