Tom 15, Nr 3 (2018)
Nefrokardiologia
Opublikowany online: 2018-12-11
Wyświetlenia strony
588
Wyświetlenia/pobrania artykułu
3160
Wpływ czynników wzrostu fibroblastów na układ sercowo-naczyniowy
Choroby Serca i Naczyń 2018;15(3):165-176.
Streszczenie
Czynniki wzrostu fibroblastów (FGF) są mediatorami sygnałowymi, które wpływają na proliferację i przeżycie komórek. Wykazano, że różne rodzaje FGF indukują przebudowę serca w warunkach fizjologicznych oraz promują angiogenezę, co
prowadzi do poprawy jego funkcji. Ponadto w stanach chorobowych FGF może skutkować apoptozą czy zwłóknieniem kardiomiocytów, co się wiąże z rozwojem dysfunkcji czy niewydolności serca (HF). W ostatnich latach wykazano, że FGF może oddziaływać na układ sercowo-naczyniowy (CV) poprzez udział w gospodarce wapniowo-fosforanowej, zwłaszcza w hiperfosfatemii u pacjentów z niewydolnością nerek. W tym kontekście udowodniono, że podwyższone stężenie, zwłaszcza
FGF23, w surowicy może bezpośrednio wpływać na kardiomiocyty poprzez receptor FGF4 (FGFR4), co przyczynia się ich przerostu w modelach przewlekłej choroby nerek, zwanej również kardiomiopatią mocznicową. Precyzyjna charakterystyka FGF, regulacja ekspresji, a co ważniejsze — identyfikacja izoform FGFR, które pośredniczą w oddziaływaniu na CV, powinny pomóc w opracowaniu nowych farmakologicznych interwencji związanych z HF, takich jak hamowanie FGFR4 w celu opanowania kardiomiopatii mocznicowej.
Słowa kluczowe: przewlekła choroba nerekczynnik wzrostu fibroblastówkardiomiopatia mocznicowa
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