open access
Vol 27, No 2 (2023)
Review paper
Published online: 2023-02-09
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Difficulties in treatment with thiazide diuretics in the elderly
1, 2
Affiliations- Calisia University, Kalisz, Poland
- Department of Hypertension, Angiology and Internal Medicine, Poznań University of Medical Sciences, Poznań, Poland
open access
Vol 27, No 2 (2023)
REVIEW
Published online: 2023-02-09
Abstract
Thiazides are in common use also in people over 65 years of age. Their side effects before the age of 60 are not very common and usually refer to the development of hypokalemia. In the elderly, the number of complications after thiazides increases significantly, and the most common side effect is hyponatremia. Although mild hyponatremia is usually asymptomatic, more severe cases may cause weakness, appetite loss, nausea, vomiting, and dizziness. However, even asymptomatic hyponatremia increases mortality. The therapy depends on the clinical picture and requires a reduction in fluid intake (in patients with symptoms of inadequate vasopressin secretion) or hydration and administration of salt solution (in patients with symptoms of decreased extracellular space).
Abstract
Thiazides are in common use also in people over 65 years of age. Their side effects before the age of 60 are not very common and usually refer to the development of hypokalemia. In the elderly, the number of complications after thiazides increases significantly, and the most common side effect is hyponatremia. Although mild hyponatremia is usually asymptomatic, more severe cases may cause weakness, appetite loss, nausea, vomiting, and dizziness. However, even asymptomatic hyponatremia increases mortality. The therapy depends on the clinical picture and requires a reduction in fluid intake (in patients with symptoms of inadequate vasopressin secretion) or hydration and administration of salt solution (in patients with symptoms of decreased extracellular space).
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Keywords
thiazides; hyponatremia; hypokalemia; squamous cell carcinoma
About this articleTitle
Difficulties in treatment with thiazide diuretics in the elderly
Journal
Issue
Article type
Review paper
Pages
63-72
Published online
2023-02-09
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1904
Article views/downloads
494
DOI
Bibliographic record
Arterial Hypertension 2023;27(2):63-72.
Keywords
thiazides
hyponatremia
hypokalemia
squamous cell carcinoma
Authors
Jerzy Głuszek
Teresa Kosicka
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