Vol 24, No 4 (2020)
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Published online: 2020-12-15

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Characteristics of calcium homeostasis in patients with different degrees of arterial hypertension

Emiliya Keledzhyyeva1, Vitalii Kaliberdenko2, Michael Shterenshis3, Shanmugaraj Kulanthaivel2, Keerthanaa Balasundaram2
Arterial Hypertension 2020;24(4):167-172.


Background: Calcium is the most common cation in the human body. An abnormal distribution of intracellular and extracellular ionized Ca plays a significant role in the formation of arterial hypertension. The purpose of the study is to analyze the fractional composition of calcium in blood serum and urinary calcium excretion in patients with hypertension, as well as to identify the features of the distribution of these.

Material and methods: The study included 80 patients. The population of the study consisted of 60 patients with various degrees of hypertension (38 women and 22 men) aged from 65 to 74 years old and the control group composed of 20 patients (12 men and 8 women) in the same age group without signs of hypertension. The patients with clinically expressed coronary heart disease requiring specific therapy, heart defects, impaired liver function and impaired kidney function were excluded from this study. Patients were divided into three groups, according to the World Health Organization (WHO) classification of arterial hypertension. Indicators of calcium concentration in blood and urine were determined using test kits for determining calcium with glyoxal bis-2 hydroxyanil from LACHEMA. To determine the ionized calcium, a standard technique of ion-selective electrode was used.

Results and conclusion:

  1. In patients with arterial hypertension, a redistribution of the calcium pool in the blood is noted due to a decrease in the concentration of ionized calcium and an increase in the bound calcium, depending on the severity of the disease.
  2. An increase in urinary calcium excretion in patients with arterial hypertension is characteristic of moderate and severe forms of arterial hypertension, which given the age of patients, may be one of the causes of osteoporosis.
  3. The increase in the level of intracellular calcium with the progression of arterial hypertension is an example of pathophysiological reactions that occur at the body level, the result of which can be not only banal muscle constriction but also a violation of the synthesis and production of biologically active substances that regulate blood pressure.

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  1. Gadallah M, Massry SG, Bigazzi R, et al. Intestinal absorption of calcium and calcium metabolism in patients with essential hypertension and normal renal function. Am J Hypertens. 1991; 4(5 Pt 1): 404–409.
  2. Haller H, Elliott HL. Review: the central role of calcium in the pathogenesis of cardiovascular disease. J Hum Hypertens. 1996; 10(3): 143–155.
  3. Hvarfner A, Bergström R, Mörlin C, et al. Relationships between calcium metabolic indices and blood pressure in patients with essential hypertension as compared with a healthy population. J Hypertens. 1987; 5(4): 451–456.
  4. Postnov YV, Orlov SN. Cell membrane alteration as a source of primary hypertension. J Hypertens. 1984; 2(1): 1–6.
  5. Polivoda SN, Vizir VA. Fraktsionnyĭ sostav kal'tsiia i soderzhanie kal'tsiĭreguliruiushchikh gormonov v plazme krovi bol'nykh gipertonicheskoĭ bolezn'iu [The fractional calcium composition and the content of calcium-regulating hormones in the blood plasma of hypertension patients]. Lik Sprava. 1994; 5(5–6): 25–29.
  6. Fleckenstein A, Fleckenstein-Grün G, Frey M, et al. Future directions in the use of calcium antagonists. Am J Cardiol. 1987; 59(3): 177B–187B.
  7. McCarron DA. Low serum concentrations of ionized calcium in patients with hypertension. N Engl J Med. 1982; 307(4): 226–228.
  8. Kaliberdenko V, Kulanthaivel S, Shterenshis M, et al. Creatinuria and Dynamics of Calcium Metabolism in Children in the Phase of Exacerbation of Bronchial Asthma. Curr Respirator Med Rev. 2020; 16(1): 28–33.
  9. Sabanayagam C, Shankar A. Serum calcium levels and hypertension among U.S. adults. J Clin Hypertens (Greenwich). 2011; 13(10): 716–721.
  10. Tsukamoto Y, Eknoyan G. National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002; 39(2 Suppl 1): S1–S266.
  11. Lyusov VA, Postnov IY, et al. Increased Erythrocyte Membrane Permeability to Sodium — A Risk Factor for Hypertension. Kardiologiia. 1984; 24(9): 88–90.
  12. Lyusov VA, Postnov IY, Karchenko VI. Erythrocyte Sodium and Sodium Flux in Relation to Hypertension in Chronic Renal Failure. Nephrol Dial Transplant. 1989.
  13. Blaustein MP, Hamlyn JM. Sodium transport inhibition, cell calcium, and hypertension. The natriuretic hormone/Na+-Ca2+ exchange/hypertension hypothesis. Am J Med. 1984; 77(4A): 45–59.
  14. Sun H, Shi J, Wang H, et al. Association of serum calcium and hypertension among adolescents aged 12-17 years in the rural area of Northeast China. Biol Trace Elem Res. 2013; 155(3): 344–351.
  15. He H, Pan Li, Du J, et al. Body Composition and Serum Total Calcium Were Associated With Blood Pressure Among Children and Adolescents Aged 7–18 in China: A Cross-Sectional Study. Front Pediatr. 2019; 7: 411.
  16. Patel RK, Jeemon P, Stevens KK, et al. Association between serum phosphate and calcium, long-term blood pressure, and mortality in treated hypertensive adults. J Hypertens. 2015; 33(10): 2046–2053.
  17. Schutte R, Huisman HW, Schutte AE, et al. Serum calcium revisited: associations with 24-h ambulatory blood pressure and cardiovascular reactivity in Africans. Hypertens Res. 2010; 33(7): 688–694.
  18. Jin Y, He L, Wang Q, et al. Serum calcium levels are not associated with coronary heart disease. Vasc Health Risk Manag. 2013; 9: 517–520.
  19. Green MS, Jucha E. Interrelationships between blood pressure, serum calcium and other biochemical variables. Int J Epidemiol. 1987; 16(4): 532–536.
  20. Kravchenko AN. The content of basal intracellular Ca and features of its receptor-dependent regulation in platelets in patients with hypertension. Abstract of Phd Dissertation 1988.
  21. Cantaro S, Calo L, Vianello A, et al. Platelet calmodulin concentration and phospholipase A2 activity in essential hypertension. Regul Pept Suppl. 1985; 4: 144–147.
  22. Sang KL, Devynck MA. Increased Platelet Cytosolic Free Calcium Concentration in Essential Hypertension. J Hypertens. 1986; 4(5): 567–574.
  23. Baksi SN. Altered pressor response to norepinephrine in calcium- and vitamin D-deficient rats. Clin Exp Hypertens A. 1988; 10(5): 811–832.
  24. McCarron DA, Morris CD, Bukoski R. The calcium paradox of essential hypertension. Am J Med. 1987; 82(1B): 27–33.
  25. Giordano G, Caraceni C, Marugo M, et al. Compartmento dell’escrezio ne urinaria di cationic mono-e bivalenti dopo carico endovenoso di calci. Arch E Maragliano Patol Clin. 1968; 24(6): 625.