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Vol 24, No 2 (2020)
Original paper
Published online: 2020-06-01
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Neutrophil-to-lymphocyte ratio and pulse wave velocity in patients with controlled systemic hypertension — a preliminary report

Andreea Varga12, Teodor Zah3, Claudia Floriana Suciu1, Dorina Nastasia Petra45, Corneliu Florin Buicu6
DOI: 10.5603/AH.a2020.0008
·
Arterial Hypertension 2020;24(2):67-73.
Affiliations
  1. Family Medicine, Department ME2 — Clinical Disciplines, Faculty of Medicine in English, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, Romania
  2. Internal Medicine II Clinic — Cardiology Department, Emergency Clinical County Hospital Targu Mures, Romania
  3. The Oncology Institute “Prof. Dr. Ion Chiricuta”, Cluj-Napoca, Romania
  4. Family Medicine, Department M4, Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, Romania
  5. Internal Medicine II Clinic, Emergency Clinical County Hospital Targu Mures, Romania
  6. Public Health and Management, Department M2 — Functional and Complementary Sciences, Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, Romania

open access

Vol 24, No 2 (2020)
ORIGINAL PAPERS
Published online: 2020-06-01

Abstract

Background. Increased arterial stiffness assessed by pulse wave velocity (PWV) measurement is a marker of arterial
wall dysfunction and has an independent predictive value for adverse cardiovascular outcomes. A positive correlation between the neutrophil-to-lymphocyte ratio (NLR) and PWV has been reported in chronic inflammatory conditions and the general population as well.

Furthermore, an association between NLR and PWV has been assumed in hypertensive patients. However, the available data are scarce.

The objective of the study was to validate the association between NLR and PWV in a homogenous group of controlled-hypertensive patients without chronic inflammatory conditions.

Material and methods. A retrospective observational study was conducted in outpatient cardiology and a general practice. A total number of 25 already on-target treated essential hypertensive, non-diabetic and non-chronic kidney disease (non-CKD) patients were selected. PWV was automatically calculated for each patient using the ABPM BPLab® device. The following laboratory data were collected: complete blood count, fibrinogen, alkaline phosphatase, lactate dehydrogenase, uric acid, serum glucose, total cholesterol, triglycerides, iron, calcium, and creatinine.

Neutrophil-to-lymphocyte ratio was calculated. Antihypertensive treatment classes were also assessed.

Results. A correlation between increased NLR and PWV in a homogenous group of controlled-hypertensive patients
was identified.

Conclusions. There is an evident relation between increased NLR and increased PWV in controlled hypertensive
patients without evidence of chronic inflammatory conditions.

Abstract

Background. Increased arterial stiffness assessed by pulse wave velocity (PWV) measurement is a marker of arterial
wall dysfunction and has an independent predictive value for adverse cardiovascular outcomes. A positive correlation between the neutrophil-to-lymphocyte ratio (NLR) and PWV has been reported in chronic inflammatory conditions and the general population as well.

Furthermore, an association between NLR and PWV has been assumed in hypertensive patients. However, the available data are scarce.

The objective of the study was to validate the association between NLR and PWV in a homogenous group of controlled-hypertensive patients without chronic inflammatory conditions.

Material and methods. A retrospective observational study was conducted in outpatient cardiology and a general practice. A total number of 25 already on-target treated essential hypertensive, non-diabetic and non-chronic kidney disease (non-CKD) patients were selected. PWV was automatically calculated for each patient using the ABPM BPLab® device. The following laboratory data were collected: complete blood count, fibrinogen, alkaline phosphatase, lactate dehydrogenase, uric acid, serum glucose, total cholesterol, triglycerides, iron, calcium, and creatinine.

Neutrophil-to-lymphocyte ratio was calculated. Antihypertensive treatment classes were also assessed.

Results. A correlation between increased NLR and PWV in a homogenous group of controlled-hypertensive patients
was identified.

Conclusions. There is an evident relation between increased NLR and increased PWV in controlled hypertensive
patients without evidence of chronic inflammatory conditions.

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Keywords

neutrophil-to-lymphocyte ratio; pulse wave velocity; hypertension

About this article
Title

Neutrophil-to-lymphocyte ratio and pulse wave velocity in patients with controlled systemic hypertension — a preliminary report

Journal

Arterial Hypertension

Issue

Vol 24, No 2 (2020)

Article type

Original paper

Pages

67-73

Published online

2020-06-01

Page views

785

Article views/downloads

695

DOI

10.5603/AH.a2020.0008

Bibliographic record

Arterial Hypertension 2020;24(2):67-73.

Keywords

neutrophil-to-lymphocyte ratio
pulse wave velocity
hypertension

Authors

Andreea Varga
Teodor Zah
Claudia Floriana Suciu
Dorina Nastasia Petra
Corneliu Florin Buicu

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