open access

Vol 23, No 4 (2019)
Original paper
Published online: 2019-12-16
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Effect of short-term physical exercise on serum markers of skeletal muscle damage in hypertensive patients treated with a combination of statin and angiotensin-converting enzyme inhibitor

Pawel Deska1, Michał Nowicki2
·
Arterial Hypertension 2019;23(4):256-262.
Affiliations
  1. Department of Internal Medicine District Hospital, Kłobuck, Poland, Poland
  2. Department of Nephrology, Medical University of Lodz, Hypertension and Kidney Transplantation, Łódź, Poland, Poland

open access

Vol 23, No 4 (2019)
ORIGINAL PAPERS
Published online: 2019-12-16

Abstract

Background. Muscle strain during physical exercise may lead to muscle damage and hyperkalaemia. Commonly prescribed drugs including statins and angiotensin-converting enzyme inhibitors (ACEI) may increase serum potassium and cause muscle damage. We postulated that the risk may be even higher if the patients are treated with a combination of statin and ACEI. The aim of the study was to compare the effect of moderate intensity short-term physical exercise on the changes of muscle injury markers serum carbonic anhydrase 3 and creatine kinase in patients with arterial hypertension receiving ACEI and statin.

Material and methods. Eighteen patients with arterial hypertension treated with ACEI were included in a prospective
placebo-controlled cross-over study. 18 healthy individuals served as controls. Hypertensive patients underwent 30-minute exercise test, which was repeated two times in a random order after the administration of ACEI with statin or ACEI with placebo. Each treatment period lasted 8 weeks separated by 2-week wash-out. Normotensive subjects underwent a single exercise test. Serum carbonic anhydrase 3 (CAIII) and creatine kinase (CK) activity were measured before and after exercise and recovery.

Results. At baseline and during the exercise CAIII was significantly higher in healthy volunteers compared to hypertensive patients. CAIII increased significantly during exercise only after treatment with both ACEI and statin. Serum CK was higher in hypertensive patients treated with ACEI plus statin during all exercise tests.

Conclusions. Addition of statin to ACEI in patients with arterial hypertension does not increase the risk of muscle damage during moderate intensity short-term physical exercise.

Abstract

Background. Muscle strain during physical exercise may lead to muscle damage and hyperkalaemia. Commonly prescribed drugs including statins and angiotensin-converting enzyme inhibitors (ACEI) may increase serum potassium and cause muscle damage. We postulated that the risk may be even higher if the patients are treated with a combination of statin and ACEI. The aim of the study was to compare the effect of moderate intensity short-term physical exercise on the changes of muscle injury markers serum carbonic anhydrase 3 and creatine kinase in patients with arterial hypertension receiving ACEI and statin.

Material and methods. Eighteen patients with arterial hypertension treated with ACEI were included in a prospective
placebo-controlled cross-over study. 18 healthy individuals served as controls. Hypertensive patients underwent 30-minute exercise test, which was repeated two times in a random order after the administration of ACEI with statin or ACEI with placebo. Each treatment period lasted 8 weeks separated by 2-week wash-out. Normotensive subjects underwent a single exercise test. Serum carbonic anhydrase 3 (CAIII) and creatine kinase (CK) activity were measured before and after exercise and recovery.

Results. At baseline and during the exercise CAIII was significantly higher in healthy volunteers compared to hypertensive patients. CAIII increased significantly during exercise only after treatment with both ACEI and statin. Serum CK was higher in hypertensive patients treated with ACEI plus statin during all exercise tests.

Conclusions. Addition of statin to ACEI in patients with arterial hypertension does not increase the risk of muscle damage during moderate intensity short-term physical exercise.

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Keywords

physical exercise; arterial hypertension; carbonic anhydrase III; creatine kinase; angiotensin-converting enzyme inhibitor; HMG-CoA reductase inhibitor

About this article
Title

Effect of short-term physical exercise on serum markers of skeletal muscle damage in hypertensive patients treated with a combination of statin and angiotensin-converting enzyme inhibitor

Journal

Arterial Hypertension

Issue

Vol 23, No 4 (2019)

Article type

Original paper

Pages

256-262

Published online

2019-12-16

Page views

999

Article views/downloads

634

DOI

10.5603/AH.a2019.0018

Bibliographic record

Arterial Hypertension 2019;23(4):256-262.

Keywords

physical exercise
arterial hypertension
carbonic anhydrase III
creatine kinase
angiotensin-converting enzyme inhibitor
HMG-CoA reductase inhibitor

Authors

Pawel Deska
Michał Nowicki

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