open access

Vol 23, No 4 (2019)
ORIGINAL PAPERS
Published online: 2019-09-16
Get Citation

The inappropriateness of left ventricular mass and echoreflectivity in males with essential hypertension and different CYP11B2 gene polymorphisms

Marina Lozinska, Vadym Zhebel, Sergiy Lozinsky
DOI: 10.5603/AH.a2019.0015
·
Arterial Hypertension 2019;23(4):240-247.

open access

Vol 23, No 4 (2019)
ORIGINAL PAPERS
Published online: 2019-09-16

Abstract

Background. The CYP11B2 gene as the main controller of aldosterone plasma activity is likely to be responsible as for the BP level as for the expression of different traits of hypertensive cardiac remodeling such as increased left ventricular mass and myocardial fibrosis. The main objective of our study was to define the differences in myocardial remodeling depending on CYP11B2 gene polymorphism. It was shown that some special techniques of echocardiography such as the assessment of inappropriate left ventricular mass and myocardial echoreflectivity proved additional information in patients with hypertensive heart disease. That’s why these techniques were used for a more precise assessment of hypertensive cardiac remodeling.

Material and methods. Our study involved 150 males aged 45–60 years. They were divided into three groups: Group 1–50 patients with normal BP without any echocardiographic abnormalities, Group 2–52 patients with essential hypertension without left ventricular hypertrophy, and Group 3–48 patients with essential hypertension and left ventricular hypertrophy.

Results. It was found that in patients with inappropriate LVM the prevalence of CC genotype was almost twice higher than among those with appropriate LVM. On the other hand, hypertensive patients with CC genotype and LVH demonstrated higher echoreflectivity parameters.

Conclusions. We assume that CC polymorphism of CYP11B2 may be an indicator of more expressed signs of hypertensive cardiac remodeling, in particular myocardial hypertrophy and myocardial fibrosis, in males with essential hypertension.

Abstract

Background. The CYP11B2 gene as the main controller of aldosterone plasma activity is likely to be responsible as for the BP level as for the expression of different traits of hypertensive cardiac remodeling such as increased left ventricular mass and myocardial fibrosis. The main objective of our study was to define the differences in myocardial remodeling depending on CYP11B2 gene polymorphism. It was shown that some special techniques of echocardiography such as the assessment of inappropriate left ventricular mass and myocardial echoreflectivity proved additional information in patients with hypertensive heart disease. That’s why these techniques were used for a more precise assessment of hypertensive cardiac remodeling.

Material and methods. Our study involved 150 males aged 45–60 years. They were divided into three groups: Group 1–50 patients with normal BP without any echocardiographic abnormalities, Group 2–52 patients with essential hypertension without left ventricular hypertrophy, and Group 3–48 patients with essential hypertension and left ventricular hypertrophy.

Results. It was found that in patients with inappropriate LVM the prevalence of CC genotype was almost twice higher than among those with appropriate LVM. On the other hand, hypertensive patients with CC genotype and LVH demonstrated higher echoreflectivity parameters.

Conclusions. We assume that CC polymorphism of CYP11B2 may be an indicator of more expressed signs of hypertensive cardiac remodeling, in particular myocardial hypertrophy and myocardial fibrosis, in males with essential hypertension.

Get Citation

Keywords

cytochrome P-450 CYP11B2; polymorphism; single nucleotide; left ventricular remodeling; essential hypertension

About this article
Title

The inappropriateness of left ventricular mass and echoreflectivity in males with essential hypertension and different CYP11B2 gene polymorphisms

Journal

Arterial Hypertension

Issue

Vol 23, No 4 (2019)

Pages

240-247

Published online

2019-09-16

DOI

10.5603/AH.a2019.0015

Bibliographic record

Arterial Hypertension 2019;23(4):240-247.

Keywords

cytochrome P-450 CYP11B2
polymorphism
single nucleotide
left ventricular remodeling
essential hypertension

Authors

Marina Lozinska
Vadym Zhebel
Sergiy Lozinsky

References (5)
  1. de Simone G, Verdecchia P, Pede S, et al. Prognosis of inappropriate left ventricular mass in hypertension: the MAVI Study. Hypertension. 2002; 40(4): 470–476.
  2. Shemirani H, Hemmati R, Khosravi A, et al. Echocardiographic assessment of inappropriate left ventricular mass and left ventricular hypertrophy in patients with diastolic dysfunction. J Res Med Sci. 2012; 17(2): 133–137.
  3. Lim YH, Lee JU, Kim KS, et al. Association between inappropriateness of left ventricular mass and left ventricular diastolic dysfunction: a study using the tissue Doppler parameter, e/e'. Korean Circ J. 2009; 39(4): 138–144.
  4. Ciulla M, Paliotti R, Hess DB, et al. Echocardiographic patterns of myocardial fibrosis in hypertensive patients: endomyocardial biopsy versus ultrasonic tissue characterization. J Am Soc Echocardiogr. 1997; 10(6): 657–664.
  5. Hiremath P, Bauer M, Cheng HW, et al. Ultrasonic assessment of myocardial microstructure. J Vis Exp. 2014(83): e50850.

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl