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Is self-reported insomnia a risk factor for subclinical carotid atherosclerosis?
, 2, 2, 2, 2, 23, 24, 23, 2
Affiliations- Almazov National Medical Research Centre, St. Petersburg, Russian Federation
- Almazov National Medical Research Centre, Russian Federation
- ITMO University, St. Petersburg, Russian Federation
- Sechenov Institute of Evolutionary Physiology and Biochemistry of RAS, St. Petersburg, Russian Federation
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Abstract
Background. Insomnia is considered an additional cardiovascular (CV) risk factor (RF). However, the data on its
association with vascular damage is controversial. We analyzed the relation between self-reported insomnia and
carotid atherosclerosis in the population-based sample.
Material and methods. We selected 985 (males — 38%; mean age 45.2 ± 11.6 years) participants of the St Petersburg
population-based sample (the ESSE-RF study) who did not have previously known CV events. All subjects
underwent a structured interview (lifestyle, medical history). Insomnia was diagnosed when complaints occurred
≥ 3 times/week (the questions: “How often did you have difficulties in falling asleep for > 30 min after going to
bed in the last month?”, “How often did you have difficulties in falling asleep after midnight awakening in the last
month?”). Subclinical atherosclerosis was assessed by carotid intima-media thickness (IMT): normal ≤ 0.9 mm,
increased IMT 0.9–13 mm, IMT > 13 mm indicated an atherosclerotic plaque.
Results. In total, 209 subjects reported at least one insomnia complaint; 79 participants (8%) reported both sleeponset
and sleep-maintenance problems. IMT thickening was found in 142 subjects (14.4%). IMT values were higher
in those with frequent nocturnal awakenings vs. non-insomniacs (0.75 ± 0.18 vs. 0.71 ± 0.17 mm, p = 0.006). They
also showed greater prevalence of thickened IMT (χ2 = 4.6, p = 0.026). Mean IMT weakly correlated with insomnia
complaints (ρ = 0.10, p = 0.002), but the association was no longer significant after adjustment for age, BP and
total cholesterol level.
Conclusion. We demonstrated an association between insomnia complaints and subclinical carotid atherosclerosis,
although we assume it to be weak compared to the common CV RF.
Abstract
Background. Insomnia is considered an additional cardiovascular (CV) risk factor (RF). However, the data on its
association with vascular damage is controversial. We analyzed the relation between self-reported insomnia and
carotid atherosclerosis in the population-based sample.
Material and methods. We selected 985 (males — 38%; mean age 45.2 ± 11.6 years) participants of the St Petersburg
population-based sample (the ESSE-RF study) who did not have previously known CV events. All subjects
underwent a structured interview (lifestyle, medical history). Insomnia was diagnosed when complaints occurred
≥ 3 times/week (the questions: “How often did you have difficulties in falling asleep for > 30 min after going to
bed in the last month?”, “How often did you have difficulties in falling asleep after midnight awakening in the last
month?”). Subclinical atherosclerosis was assessed by carotid intima-media thickness (IMT): normal ≤ 0.9 mm,
increased IMT 0.9–13 mm, IMT > 13 mm indicated an atherosclerotic plaque.
Results. In total, 209 subjects reported at least one insomnia complaint; 79 participants (8%) reported both sleeponset
and sleep-maintenance problems. IMT thickening was found in 142 subjects (14.4%). IMT values were higher
in those with frequent nocturnal awakenings vs. non-insomniacs (0.75 ± 0.18 vs. 0.71 ± 0.17 mm, p = 0.006). They
also showed greater prevalence of thickened IMT (χ2 = 4.6, p = 0.026). Mean IMT weakly correlated with insomnia
complaints (ρ = 0.10, p = 0.002), but the association was no longer significant after adjustment for age, BP and
total cholesterol level.
Conclusion. We demonstrated an association between insomnia complaints and subclinical carotid atherosclerosis,
although we assume it to be weak compared to the common CV RF.
Keywords
insomnia; carotid atherosclerosis; subclinical atherosclerosis; cardiovascular risk factors; cardiovascular prevention
About this articleTitle
Is self-reported insomnia a risk factor for subclinical carotid atherosclerosis?
Journal
Issue
Article type
Original paper
Pages
105-113
Published online
2019-04-26
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1274
Article views/downloads
723
DOI
Bibliographic record
Arterial Hypertension 2019;23(2):105-113.
Keywords
insomnia
carotid atherosclerosis
subclinical atherosclerosis
cardiovascular risk factors
cardiovascular prevention
Authors
Lyudmila Korostovtseva
Asiiat Alieva
Oxana Rotar
Mikhail Bochkarev
Maria Boyarinova
Nadezhda Zvartau
Yurii Sviryaev
Aleksandra Konradi
Eugene Shlyakhto
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