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Protective effect of nebivolol to prevent target organ damage in hypertension
Affiliations- Klinika Hipertensjologii i Chorób Wewnętrznych, Pomorski Uniwersytet Medyczny, Szczecin, Poland
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Abstract
Cardiovascular complications (left ventricular hypertrophy, atrial fibrillation, heart failure, coronary events, increased arterial stiffness and atherosclerotic lesions) are the major causes of death among patients with hypertension. Oxidative stress and central aortic pressure play a key role in the pathophysiology of the cardiovascular diseases and complications. Antihypertensive agents may, even within the same class of drugs, exert variable effects on arterial stiffness parameters and endothelial function. Nebivolol is a third-generation β-blocker with vasodilator activity. Its vasodilatory function is mediated by the endothelial L-arginine/NO pathway. Nebivolol increases the bioavailability of NO in the vasculature. Recent studies have demonstrated that nebivolol improves arterial stiffness to a greater extent than conventional β-adrenolytics (atenolol, metoprolol). According to ESH/ESC guidelines, some of the vasodilating β-adrenolytics, such as celiprolol, carvedilol and nebivolol, provide greater reduction in central pulse pressure and aortic stiffness than atenolol or metoprolol.
Abstract
Cardiovascular complications (left ventricular hypertrophy, atrial fibrillation, heart failure, coronary events, increased arterial stiffness and atherosclerotic lesions) are the major causes of death among patients with hypertension. Oxidative stress and central aortic pressure play a key role in the pathophysiology of the cardiovascular diseases and complications. Antihypertensive agents may, even within the same class of drugs, exert variable effects on arterial stiffness parameters and endothelial function. Nebivolol is a third-generation β-blocker with vasodilator activity. Its vasodilatory function is mediated by the endothelial L-arginine/NO pathway. Nebivolol increases the bioavailability of NO in the vasculature. Recent studies have demonstrated that nebivolol improves arterial stiffness to a greater extent than conventional β-adrenolytics (atenolol, metoprolol). According to ESH/ESC guidelines, some of the vasodilating β-adrenolytics, such as celiprolol, carvedilol and nebivolol, provide greater reduction in central pulse pressure and aortic stiffness than atenolol or metoprolol.
Keywords
nebivolol, hypertension, target organ damage, central aortic pressure
About this articleTitle
Protective effect of nebivolol to prevent target organ damage in hypertension
Journal
Issue
Article type
Editorial
Pages
1-8
Published online
2018-03-30
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1543
Article views/downloads
1868
DOI
Bibliographic record
Arterial Hypertension 2018;22(1):1-8.
Keywords
nebivolol
hypertension
target organ damage
central aortic pressure
Authors
Krystyna Widecka
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