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Serum inflammatory markers as predictors of neurological status in patients with stroke in the course of hypertension: a two-center study
Affiliations- Department of Neurology, SMDZ in Zabrze, Medical University of Silesia in Katowice, Poland, ul. 3 maja 13-15, 41-800 Zabrze, Poland
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Abstract
Introduction. Every year, 60.000 people have stroke incidents in Poland. Despite the fact that it can be prevented, stroke remains the leading cause of morbidity and mortality worldwide. Hypertension is one of the leading risk factors for the stroke incident. The aim was to assess the relationship between inflammatory markers and clinical status of hypertensive patients with the stroke.
Material and methods. 713 patients with stroke in the course of hypertension from the Departments of Neurology in Bytom and Zabrze were enrolled in the retrospective study. They were divided into groups: N1, R1 (with improvement in NIHSS and Rankin results, respectively) and N2, R2 (with deterioration or no changes in NIHSS and Rankin between the day of admission and discharge).
Results. The majority of patients were females [%] (51.5 vs 48.5). Women were significantly older than man [years] (78.0 vs 69.0, P = 0.001, respectively) and had higher NIHSS results at admission [points] (6.0 vs 5.0, P = 0.001, respectively). There were significant differences in the serum CRP [mg/l] (4.75 vs 9.40, P = 0.001) and WBC [103/μL] (8.58 vs 9.02, P = 0.006) between N1 and N2, respectively and between R1 and R2: WBC (8.50 vs 9.00, P = 0.006) and CRP (4.20 vs 8.70, P = 0.001), respectively. A significant correlation between CRP and NIHSS on admission was observed (R = 0.191, P < 0.05). NIHSS and Rankin score on admission were correlated with age (R = 0.212, and R = 0.231, P < 0.05, respectively). CRP was related with the volume [cm3] of lesions in CT (R = 0.170, P < 0.05).
Conclusions. Inflammation seems to be associated with the worse neurological status of patients with stroke and hypertension. Age and sex affect the clinical course of stroke. CRP may indicate the size of changes in CT.
Abstract
Introduction. Every year, 60.000 people have stroke incidents in Poland. Despite the fact that it can be prevented, stroke remains the leading cause of morbidity and mortality worldwide. Hypertension is one of the leading risk factors for the stroke incident. The aim was to assess the relationship between inflammatory markers and clinical status of hypertensive patients with the stroke.
Material and methods. 713 patients with stroke in the course of hypertension from the Departments of Neurology in Bytom and Zabrze were enrolled in the retrospective study. They were divided into groups: N1, R1 (with improvement in NIHSS and Rankin results, respectively) and N2, R2 (with deterioration or no changes in NIHSS and Rankin between the day of admission and discharge).
Results. The majority of patients were females [%] (51.5 vs 48.5). Women were significantly older than man [years] (78.0 vs 69.0, P = 0.001, respectively) and had higher NIHSS results at admission [points] (6.0 vs 5.0, P = 0.001, respectively). There were significant differences in the serum CRP [mg/l] (4.75 vs 9.40, P = 0.001) and WBC [103/μL] (8.58 vs 9.02, P = 0.006) between N1 and N2, respectively and between R1 and R2: WBC (8.50 vs 9.00, P = 0.006) and CRP (4.20 vs 8.70, P = 0.001), respectively. A significant correlation between CRP and NIHSS on admission was observed (R = 0.191, P < 0.05). NIHSS and Rankin score on admission were correlated with age (R = 0.212, and R = 0.231, P < 0.05, respectively). CRP was related with the volume [cm3] of lesions in CT (R = 0.170, P < 0.05).
Conclusions. Inflammation seems to be associated with the worse neurological status of patients with stroke and hypertension. Age and sex affect the clinical course of stroke. CRP may indicate the size of changes in CT.
Keywords
stroke, hypertension, NIHSS, Rankin, inflammation, CRP, WBC
About this articleTitle
Serum inflammatory markers as predictors of neurological status in patients with stroke in the course of hypertension: a two-center study
Journal
Issue
Article type
Original paper
Pages
87-94
Published online
2018-06-29
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1338
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920
DOI
Bibliographic record
Arterial Hypertension 2018;22(2):87-94.
Keywords
stroke
hypertension
NIHSS
Rankin
inflammation
CRP
WBC
Authors
Martyna Anna Nowak
Maria Magdalena Nowak
Paula Irmina Walczak
Maciej Wojciech Olszewski
Natalia Niedziela MD, PhD
Paweł Warmus MD
Monika Adamczyk-Sowa MD, PhD
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