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Can hypertensive therapy reduce the risk of cognitive impairment and dementia?
Affiliations- Klinika Hipertensjologii i Chorób Wewnętrznych, Samodzielny Publiczny Szpital Kliniczny Nr 1 w Szczecinie, Poland
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Abstract
Hypertension is an important risk factor for cardiovascular diseases and dementia. The efficacy of antihypertensive therapy, however, is still insufficient. Combination therapy of hypertension at least two drugs achieves the target blood pressure. The combination of perindopril and amlodipine is extensively studied well the combination of drugs, for which demonstrated a reduction in total mortality and cardiovascular events and stroke.
The review explores molecular and clinical studies that might help explain the relation between the renin-angiotensin system, hypertension, and dementia and whether treatment with ACE inhibitor (perindopril) and CCB (amlodipine) have a part to play in the management of the disease.
Abstract
Hypertension is an important risk factor for cardiovascular diseases and dementia. The efficacy of antihypertensive therapy, however, is still insufficient. Combination therapy of hypertension at least two drugs achieves the target blood pressure. The combination of perindopril and amlodipine is extensively studied well the combination of drugs, for which demonstrated a reduction in total mortality and cardiovascular events and stroke.
The review explores molecular and clinical studies that might help explain the relation between the renin-angiotensin system, hypertension, and dementia and whether treatment with ACE inhibitor (perindopril) and CCB (amlodipine) have a part to play in the management of the disease.
Keywords
perindopril/amlodypina, essential hypertension, cardioprotection, dementia, Alzheimer’s disease
About this articleTitle
Can hypertensive therapy reduce the risk of cognitive impairment and dementia?
Journal
Issue
Article type
Editorial
Pages
61-68
Published online
2017-06-30
Page views
985
Article views/downloads
1216
DOI
Bibliographic record
Arterial Hypertension 2017;21(2):61-68.
Keywords
perindopril/amlodypina
essential hypertension
cardioprotection
dementia
Alzheimer’s disease
Authors
Krystyna Widecka
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