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Study of the role of L-arginine in the diagnosis of pregnancy-induced hypertension
open access
Abstract
Background Pregnancy-induced hypertension (PIH) is a significant health issue in pregnancy, complicating 7–10% of pregnancies. L-arginine is an important mediator of vasodilation with a potential preventative role in pregnancy-related hypertensive diseases.
Aim of the study The aim of the present study was to assess the differences in plasma L-arginine concentrations in physiological pregnancies and pregnancies complicated with hypertension in the third trimester.
Material and methods Plasma concentration of L-arginine was determined by ion-exchange chromatography in 210 pregnant women (25–41 weeks of gestation). Plasma L-arginine concentration was expressed in μmol/cm3.
Results The mean L-arginine concentration was significantly higher in physiological pregnancy (0.102) than in the PIH group (0.034). The analysis of plasma L-arginine concentration in the subgroups of third trimester showed that L-arginine concentration in the PIH group decreased with increasing stage of pregnancy (25–34 hbd — 0.051; 35–38 hbd — 0.03; 39–41 hbd — 0.02). L-arginine concentration in physiological pregnancies was the same in all subgroups (0.1).
Conclusions L-arginine may have a role in the prevention and treatment of pregnancy-induced hypertension. Further well-designed and adequately powered research is warranted.
Abstract
Background Pregnancy-induced hypertension (PIH) is a significant health issue in pregnancy, complicating 7–10% of pregnancies. L-arginine is an important mediator of vasodilation with a potential preventative role in pregnancy-related hypertensive diseases.
Aim of the study The aim of the present study was to assess the differences in plasma L-arginine concentrations in physiological pregnancies and pregnancies complicated with hypertension in the third trimester.
Material and methods Plasma concentration of L-arginine was determined by ion-exchange chromatography in 210 pregnant women (25–41 weeks of gestation). Plasma L-arginine concentration was expressed in μmol/cm3.
Results The mean L-arginine concentration was significantly higher in physiological pregnancy (0.102) than in the PIH group (0.034). The analysis of plasma L-arginine concentration in the subgroups of third trimester showed that L-arginine concentration in the PIH group decreased with increasing stage of pregnancy (25–34 hbd — 0.051; 35–38 hbd — 0.03; 39–41 hbd — 0.02). L-arginine concentration in physiological pregnancies was the same in all subgroups (0.1).
Conclusions L-arginine may have a role in the prevention and treatment of pregnancy-induced hypertension. Further well-designed and adequately powered research is warranted.
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Keywords
L-arginine, pregnant women, hypertension, blood plasma
About this articleTitle
Study of the role of L-arginine in the diagnosis of pregnancy-induced hypertension
Journal
Issue
Article type
Original paper
Pages
113-118
Published online
2016-09-29
Page views
854
Article views/downloads
1526
DOI
10.5603/AH.2016.0017
Bibliographic record
Arterial Hypertension 2016;20(3):113-118.
Keywords
L-arginine
pregnant women
hypertension
blood plasma
Authors
Agnieszka Grafka
Maciej Łopucki
Katarzyna Karwasik-Kajszczarek
Marzena Stasiak-Kosarzycka
Andrzej Miturski
Grzegorz Dzida