open access
Hypertension and beyond — does circulating irisin matter?
open access
Abstract
Irisin is a myokine secreted by skeletal muscles. It has been proposed to drive the brown-fat-like conversion of the white adipose tissue. By enhancing energy expenditure, irisin may affect systemic metabolism and be associated with insulin resistance; however, the mechanism(s) of action still remain largely unexplained. The discovery of irisin can contribute to the exploration of the novel and effective therapeutic targets or therapeutic strategies of metabolic diseases or metabolism-associated health issues. In this review, based on the recent literature (from 2013 to 2015 inclusive), we will systematically discuss the associations of irisin with obesity, type 2 diabetes, lipid disorders, and hypertension. We also introduce unanswered questions for future research.
Abstract
Irisin is a myokine secreted by skeletal muscles. It has been proposed to drive the brown-fat-like conversion of the white adipose tissue. By enhancing energy expenditure, irisin may affect systemic metabolism and be associated with insulin resistance; however, the mechanism(s) of action still remain largely unexplained. The discovery of irisin can contribute to the exploration of the novel and effective therapeutic targets or therapeutic strategies of metabolic diseases or metabolism-associated health issues. In this review, based on the recent literature (from 2013 to 2015 inclusive), we will systematically discuss the associations of irisin with obesity, type 2 diabetes, lipid disorders, and hypertension. We also introduce unanswered questions for future research.
Keywords
irisin; hypertension; metabolic diseases; diabetes
About this articleTitle
Hypertension and beyond — does circulating irisin matter?
Journal
Issue
Article type
Review paper
Pages
16-20
Published online
2016-03-31
Page views
1226
Article views/downloads
2054
DOI
10.5603/AH.2016.0004
Bibliographic record
Arterial Hypertension 2016;20(1):16-20.
Keywords
irisin
hypertension
metabolic diseases
diabetes
Authors
Aleksandra Taszarek
Anna Kaczmarkiewicz
Tomasz Miazgowski
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