open access
Renal tubulointerstitial tissue damage, central pressure and vascular function in patients with untreated primary arterial hypertension
open access
Abstract
Material and methods 25 patients with untreated primary arterial hypertension without albuminuria and 15 healthy volunteers underwent arterial pressure measurement with a standard mercury sphygmomanometer using the Korotkoff technique and non-invasive measurement of aortic pressure by applanation tonometry using a SphygmoCor device. For all subjects, the concentrations of creatinine, uric acid, 1,25(OH)2D3, erythropoietin, and 25-hour NAG excretion were determined and GFR was estimated using the MDRD equation. PWV measurement was performed using a SphygmoCor device, whereas IMT was measured by ultrasound.
Results Hypertensive patients showed higher values of arterial pressure compared to the control group: SBP, DBP, PP, MAP, as well as CSP, CDP, CPP and MCAP. In both the studied and the control group, the following statistically significant positive correlations were found: CPP vs IMT and CPP vs AIx. Only in the studied group, the following positive linear correlations were found: NAG vs PWV (R = 0.46; p = 0.019); NAG vs IMT (R = 0.36; p = 0.078). In the multiple regression model, a statistically significant positive effect was found of PWV and IMT [PWV (b 0.41; p = 0.0158), IMT (b 0.49; p = 0.0048)] on the dependent variable NAG (R2 = 0.503) in hypertensive patients. eGFR or uric acid concentration in serum included additionally in the model had no statistically significant effect on the dependent variable NAG (p = 0.9307 and p = 0.4938, respectively).
Conclusions Damage to the renal tubulointerstitial tissue in hypertensive patients is concomitant with a decrease in vascular resistance. CPP may constitute a useful parameter for assessing the development of atherosclerotic lesions in vessels and the function of the left ventricle of the heart.
Abstract
Material and methods 25 patients with untreated primary arterial hypertension without albuminuria and 15 healthy volunteers underwent arterial pressure measurement with a standard mercury sphygmomanometer using the Korotkoff technique and non-invasive measurement of aortic pressure by applanation tonometry using a SphygmoCor device. For all subjects, the concentrations of creatinine, uric acid, 1,25(OH)2D3, erythropoietin, and 25-hour NAG excretion were determined and GFR was estimated using the MDRD equation. PWV measurement was performed using a SphygmoCor device, whereas IMT was measured by ultrasound.
Results Hypertensive patients showed higher values of arterial pressure compared to the control group: SBP, DBP, PP, MAP, as well as CSP, CDP, CPP and MCAP. In both the studied and the control group, the following statistically significant positive correlations were found: CPP vs IMT and CPP vs AIx. Only in the studied group, the following positive linear correlations were found: NAG vs PWV (R = 0.46; p = 0.019); NAG vs IMT (R = 0.36; p = 0.078). In the multiple regression model, a statistically significant positive effect was found of PWV and IMT [PWV (b 0.41; p = 0.0158), IMT (b 0.49; p = 0.0048)] on the dependent variable NAG (R2 = 0.503) in hypertensive patients. eGFR or uric acid concentration in serum included additionally in the model had no statistically significant effect on the dependent variable NAG (p = 0.9307 and p = 0.4938, respectively).
Conclusions Damage to the renal tubulointerstitial tissue in hypertensive patients is concomitant with a decrease in vascular resistance. CPP may constitute a useful parameter for assessing the development of atherosclerotic lesions in vessels and the function of the left ventricle of the heart.
Keywords
arterial hypertension, CPP, NAG, vessels
Title
Renal tubulointerstitial tissue damage, central pressure and vascular function in patients with untreated primary arterial hypertension
Journal
Issue
Article type
Original paper
Pages
29-38
Published online
2015-03-31
Page views
1015
Article views/downloads
1785
DOI
10.5603/AH.2015.0006
Bibliographic record
Arterial Hypertension 2015;19(1):29-38.
Keywords
arterial hypertension
CPP
NAG
vessels
Authors
Rafał Bednarski
Piotr Kubalski
Anna Stefańska
Grażyna Odrowąż-Sypniewska
Jacek Manitius