open access

Vol 27, No 2 (2023)
Review paper
Published online: 2023-02-09
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Difficulties in treatment with thiazide diuretics in the elderly

Jerzy Głuszek1, Teresa Kosicka2
·
Arterial Hypertension 2023;27(2):63-72.
Affiliations
  1. Calisia University, Kalisz, Poland
  2. Department of Hypertension, Angiology and Internal Medicine, Poznań University of Medical Sciences, Poznań, Poland

open access

Vol 27, No 2 (2023)
REVIEW
Published online: 2023-02-09

Abstract

Thiazides are in common use also in people over 65 years of age. Their side effects before the age of 60 are not very common and usually refer to the development of hypokalemia. In the elderly, the number of complications after thiazides increases significantly, and the most common side effect is hyponatremia. Although mild hyponatremia is usually asymptomatic, more severe cases may cause weakness, appetite loss, nausea, vomiting, and dizziness. However, even asymptomatic hyponatremia increases mortality. The therapy depends on the clinical picture and requires a reduction in fluid intake (in patients with symptoms of inadequate vasopressin secretion) or hydration and administration of salt solution (in patients with symptoms of decreased extracellular space).

 

Abstract

Thiazides are in common use also in people over 65 years of age. Their side effects before the age of 60 are not very common and usually refer to the development of hypokalemia. In the elderly, the number of complications after thiazides increases significantly, and the most common side effect is hyponatremia. Although mild hyponatremia is usually asymptomatic, more severe cases may cause weakness, appetite loss, nausea, vomiting, and dizziness. However, even asymptomatic hyponatremia increases mortality. The therapy depends on the clinical picture and requires a reduction in fluid intake (in patients with symptoms of inadequate vasopressin secretion) or hydration and administration of salt solution (in patients with symptoms of decreased extracellular space).

 

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Keywords

thiazides; hyponatremia; hypokalemia; squamous cell carcinoma

About this article
Title

Difficulties in treatment with thiazide diuretics in the elderly

Journal

Arterial Hypertension

Issue

Vol 27, No 2 (2023)

Article type

Review paper

Pages

63-72

Published online

2023-02-09

Page views

1868

Article views/downloads

459

DOI

10.5603/AH.a2023.0006

Bibliographic record

Arterial Hypertension 2023;27(2):63-72.

Keywords

thiazides
hyponatremia
hypokalemia
squamous cell carcinoma

Authors

Jerzy Głuszek
Teresa Kosicka

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