Assessment of atherogenic indices and lipid ratios in the apparently healthy women aged 30–55 years
, 2, 3
Abstract
Background: Cardiovascular disease (CVD) is the main cause of death worldwide and atherogenic dyslipidemia is an established risk factor for CVD. This cross-sectional study aimed to assess the atherogenic indices and lipid ratios, including atherogenic coefficient (AC), atherogenic index of plasma (AIP), cholindex (CI), Castelli risk index-1 (CRI-1), CRI-2, and non-HDL-C, in women living in the Tabriz, Iran during April–May 2017.
Material and methods: Anthropometric measurements, fasting serum lipids, and blood pressure of 150 women aged 30–55 years in Tabriz, Iran was evaluated. The atherogenic indices were calculated by the established formulas.
Results: The prevalence of high AIP, AC, CI, CRI-1, CRI-2 and non-HDL-C ratios were 64.5%, 36.2%, 20.4%, 77%, 7.2% and 44.7%, respectively. In the multiple-adjusted quantile regression analysis, significant relationships were found between CI ratio and diastolic blood pressure (DBP) (B = 3.76, p = 0.035) and between CRI-2 ratio and DBP (B = 0.005, p = 0.042) and age (B = 0.005, p = 0.031).
Conclusions: This study indicated that the majority of studied women had a high risk of CVD based on atherogenic indices. Further public health efforts are required to enhance awareness of women and healthcare providers about preventing and controlling CVD risk.
Keywords: atherogenic indiceslipid ratiosdyslipidemiacardiovascular risk factorswomen
References
- Desai G, R R, Akka K, et al. A cross sectional study of serum gamaglutamyl transferase acitivity with reference to atherogenic lipid indices in patients with ischemic heart disease. J Evolut Med Dental Sci. 2014; 3(10): 2655–2662.
- Sadeghi M, Haghdoost AA, Bahrampour A, et al. Modeling the Burden of Cardiovascular Diseases in Iran from 2005 to 2025: The Impact of Demographic Changes. Iran J Public Health. 2017; 46(4): 506–516.
- Niroumand S, Khajedaluee M, Khadem-Rezaiyan M, et al. Atherogenic Index of Plasma (AIP): A marker of cardiovascular disease. Med J Islam Repub Iran. 2015; 29: 240.
- Schaefer EJ, Lamon-Fava S, Johnson S, et al. Effects of age, sex, and menopausal status on plasma lipoprotein(a) levels. The Framingham Offspring Study. Circulation. 1993; 87(4): 1135–1141.
- Maas AH, van der Schouw YT, Regitz-Zagrosek V, et al. Red alert for women's heart: the urgent need for more research and knowledge on cardiovascular disease in women: proceedings of the workshop held in Brussels on gender differences in cardiovascular disease, 29 September 2010. Eur Heart J. 2011; 32(11): 1362–1368.
- Lee MiJ, Park JT, Han SH, et al. The atherogenic index of plasma and the risk of mortality in incident dialysis patients: Results from a nationwide prospective cohort in Korea. PLoS One. 2017; 12(5): e0177499.
- Rosolová H, Dobiášová M, Soška V, et al. Combined therapy of mixed dyslipidemia in patients with high cardiovascular risk and changes in the lipid target values and atherogenic index of plasma. Cor et Vasa. 2014; 56(2): e133–e139.
- Noumegni SR, Nansseu JR, Bigna JJ, et al. Atherogenic index of plasma and 10-year risk of cardiovascular disease in adult Africans living with HIV infection: A cross-sectional study from Yaoundé, Cameroon. JRSM Cardiovasc Dis. 2017; 6: 2048004017740478.
- Mannangi NB. Novel lipid indices in chronic kidney disease. Age. 2015; 19(1077): 4983–4989.
- Bendzala M, Sabaka P, Caprnda M, et al. Atherogenic index of plasma is positively associated with the risk of all-cause death in elderly women : A 10-year follow-up. Wien Klin Wochenschr. 2017; 129(21-22): 793–798.
- Ni W, Zhou Z, Liu T, et al. Gender-and lesion number-dependent difference in "atherogenic index of plasma" in Chinese people with coronary heart disease. Sci Rep. 2017; 7(1): 13207.
- Yıldız A, Seçen Ö, Yıldız C, et al. Relationship between breast arterial calcification and lipid profile, plasma atherogenic index, Castelli's risk index and atherogenic coefficient in premenopausal women. IJC Metab Endocrine. 2016; 11: 19–22.
- Akpınar O, Bozkurt A, Acartürk E, et al. A new index (CHOLINDEX) in detecting coronary artery disease risk. Anadolu Kardiyol Derg. 2013; 13(4): 315–319.
- Wu J, Chen S, Zhou Y, et al. Non-high-density lipoprotein cholesterol vs low-density lipoprotein cholesterol as a risk factor for ischemic stroke: a result from the Kailuan study. Neurol Res. 2013; 35(5): 505–511.
- Sujatha R, Kavitha S. Atherogenic indices in stroke patients: A retrospective study. Iran J Neurol. 2017; 16(2): 78–82.
- Gupta S, Gudapati R, Gaurav K, et al. Emerging risk factors for cardiovascular diseases: Indian context. Indian J Endocrinol Metab. 2013; 17(5): 806–814.
- Mahan LK, Raymond JL. rause's food & the nutrition care process-e-book. Elsevier Health Sciences, New York 2016.
- Health UNIo. Clinical guidelines for the identification, evaluation, and treatment of overweight and obesity in adults Bethesda. National Institutes of Health 1998.
- Zhong X, Guo L, Zhang L, et al. Hs-CRP and all-cause, cardiovascular, and cancer mortality risk: A meta-analysis. Atherosclerosis. 2017; 259(1): 75–82.
- Holvoet P, Lee DH, Steffes M, et al. Association between circulating oxidized low-density lipoprotein and incidence of the metabolic syndrome. JAMA. 2008; 299(19): 2287–2293.
- Olamoyegun MA, Oluyombo R, Asaolu SO. Evaluation of dyslipidemia, lipid ratios, and atherogenic index as cardiovascular risk factors among semi-urban dwellers in Nigeria. Ann Afr Med. 2016; 15(4): 194–199.
- Emokpae MA, Arogundade A, Adumanya SC. Use of atherogenic index of plasma in evaluating the potential cardioprotective effects of red wine consumption: Studies in Nigerian young adult volunteers. Biokemistri. 2013; 25(3): 118–23.
- Nimmanapalli H, Kasi A, Devapatla P, et al. Lipid ratios, atherogenic coefficient and atherogenic index of plasma as parameters in assessing cardiovascular risk in type 2 diabetes mellitus. Int J Res Med Sci. 2016: 2863–2869.
- Kumpatla S, Soni A, Narasingan SN, et al. Presence of elevated non-HDL among patients with T2DM with CV events despite of optimal LDL-C - A report from South India. Indian Heart J. 2016; 68(3): 378–379.
- Singh M, Pathak MS, Paul A. A Study on Atherogenic Indices of Pregnancy Induced Hypertension Patients as Compared to Normal Pregnant Women. J Clin Diagn Res. 2015; 9(7): BC05–BC08.
- Kazemi T, Hajihosseini M, Moossavi M, et al. Cardiovascular Risk Factors and Atherogenic Indices in an Iranian Population: Birjand East of Iran. Clin Med Insights Cardiol. 2018; 12: 1179546818759286.