Vol 24, No 4 (2020)
Published online: 2020-12-03

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Risk factors and potential outcomes of COVID-2019 — a narrative review with focus on cardiovascular health

Anna Ryś-Czaporowska1, Krystyna Widecka2, Karolina Semczuk-Kaczmarek1, Anna E. Płatek3, Waldemar Cisło4, Filip M. Szymański1
Arterial Hypertension 2020;24(4):143-147.


Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2), spreads rapidly and has been announced a pandemic by the World Health Organization (WHO). COVID-19 especially affects cardiovascular system, mostly by leading to the dysfunction of endothelium and its consequences. On the other hand, patients with a history of chronic disease are believed to have a more severe course of COVID-19. Furthermore, apart from an undoubted influence on morbidity and mortality, COVID-19 results in changes in many aspects of human life. It is worth noting that pandemic will also affect people who did not suffer from disease. Nevertheless, due to constantly elevated stress level, COVID-19 may have influence on mental health. Paradoxically, in dealing with stress and COVID-related problems, faith and religiosity can play a leading role. In this review, attention was paid not only to possible cardiac complications of infection but also to the impact of the pandemic on psychological and spiritual effects of the pandemic.  

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  1. https://www.who.int/emergencies/diseases/novel-coronavirus-2019.
  2. ESC Guidance for the Diagnosis and Management of CV Disease during the COVID-19 Pandemic. https://www.escardio.org/Education/COVID-19-and-Cardiology/ESC-COVID-19-Guidance.
  3. Ackermann M, Verleden SE, Kuehnel M, et al. Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19. N Engl J Med. 2020; 383(2): 120–128.
  4. Wang X, Sahu KK, Cerny J. Coagulopathy, endothelial dysfunction, thrombotic microangiopathy and complement activation: potential role of complement system inhibition in COVID-19. J Thromb Thrombolysis. 2020 [Epub ahead of print].
  5. Xiong TY, Redwood S, Prendergast B, et al. Coronaviruses and the cardiovascular system: acute and long-term implications. Eur Heart J. 2020; 41(19): 1798–1800.
  6. Ameri P, Inciardi RM, Di Pasquale M, et al. Pulmonary embolism in patients with COVID-19: characteristics and outcomes in the Cardio-COVID Italy multicenter study. Clin Res Cardiol. 2020 [Epub ahead of print].
  7. Klok FA, Kruip MJ, van der Meer NJM, et al. Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis. Thromb Res. 2020; 191: 148–150.
  8. Pardo Sanz A, Salido Tahoces L, Ortega Pérez R, et al. New-onset atrial fibrillation during COVID-19 infection predicts poor prognosis. Cardiol J. 2020 [Epub ahead of print].
  9. Shchedrygina A, Nagel E, Puntmann VO, et al. COVID-19 myocarditis and prospective heart failure burden. Expert Rev Cardiovasc Ther. 2020 [Epub ahead of print].
  10. Okura H. Update of takotsubo syndrome in the era of COVID-19. J Cardiol. 2020 [Epub ahead of print].
  11. Santoro F, Monitillo F, Raimondo P, et al. QTc interval prolongation and life-threatening arrhythmias during hospitalization in patients with COVID-19. Results from a multi-center prospective registry. Clin Infect Dis. 2020 [Epub ahead of print].
  12. Wang D, Hu Bo, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020; 323(11): 1061–1069.
  13. Li J, Huang DQ, Zou B, et al. Epidemiology of COVID-19: A systematic review and meta-analysis of clinical characteristics, risk factors, and outcomes. J Med Virol. 2020 [Epub ahead of print].
  14. Ssentongo P, Ssentongo AE, Heilbrunn ES, et al. Association of cardiovascular disease and 10 other pre-existing comorbidities with COVID-19 mortality: A systematic review and meta-analysis. PLoS One. 2020; 15(8): e0238215.
  15. Khan MdM, Khan MdN, Mustagir MdG, et al. Effects of underlying morbidities on the occurrence of deaths in COVID-19 patients: A systematic review and meta-analysis. J Glob Health. 2020; 10(2): 020503.
  16. Alvarez-Garcia J, Lee S, Gupta A, et al. Prognostic Impact of Prior Heart Failure in Patients Hospitalized With COVID-19. J Am Coll Cardiol. 2020; 76(20): 2334–2348.
  17. Zhang B, Dong C, Li S, et al. Triglyceride to High-Density Lipoprotein Cholesterol Ratio is an Important Determinant of Cardiovascular Risk and Poor Prognosis in Coronavirus Disease-19: A Retrospective Case Series Study. Diabetes Metab Syndr Obes. 2020; 13: 3925–3936.
  18. Zandifar A, Badrfam R, Yazdani S, et al. Prevalence and severity of depression, anxiety, stress and perceived stress in hospitalized patients with COVID-19. J Diabetes Metab Disord. 2020 [Epub ahead of print]: 1–8.
  19. García-Álvarez L, Fuente-Tomás Ld, García-Portilla M, et al. Early psychological impact of the 2019 coronavirus disease (COVID-19) pandemic and lockdown in a large Spanish sample. J Glob Health. 2020; 10(2).
  20. Guo Q, Zheng Y, Shi J, et al. Immediate psychological distress in quarantined patients with COVID-19 and its association with peripheral inflammation: A mixed-method study. Brain Behav Immun. 2020; 88: 17–27.
  21. Hong BA, Handal PJ. Science, Religion, Government, and SARS-CoV-2: A Time for Synergy. J Relig Health. 2020; 59(5): 2263–2268.
  22. Janssen DJA, Ekström M, Currow DC, et al. COVID-19: guidance on palliative care from a European Respiratory Society international task force. Eur Respir J. 2020; 56(3).
  23. Ferrell BR, Handzo G, Picchi T, et al. The Urgency of Spiritual Care: COVID-19 and the Critical Need for Whole-Person Palliation. J Pain Symptom Manage. 2020; 60(3): e7–ee11.
  24. Lucchetti G, Góes LG, Amaral SG, et al. Spirituality, religiosity and the mental health consequences of social isolation during Covid-19 pandemic. Int J Soc Psychiatry. 2020; 20764020970996: [Ahead of print].
  25. Chirico F, Nucera G. An Italian Experience of Spirituality from the Coronavirus Pandemic. J Relig Health. 2020; 59(5): 2193–2195.
  26. Psotka MA, Abraham WT, Fiuzat M, et al. Conduct of Clinical Trials in the Era of COVID-19: JACC Scientific Expert Panel. J Am Coll Cardiol. 2020; 76(20): 2368–2378.