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LACK OF ASSOCIATION BETWEEN ANGIOTENSIN-CONVERTING ENZYME (ACE) GENOTYPE AND ESSENTIAL HYPERTENSION IN PERUVIAN OLDER PEOPLE

Teodoro J. Oscanoa, Edwin C. Cieza, Frank A. Lizaraso-Soto, María L. Guevara, Ricardo M. Fujita, Roman Romero-Ortuno
DOI: 10.5603/AH.a2020.0011

open access

Ahead of print
ORIGINAL PAPERS
Published online: 2020-09-07

Abstract

Background: Epidemiological studies have shown an association between the ACE gene I / D polymorphism with arterial hypertension, specifically the DD genotype in different populations. The objective of this study is to evaluate the association between ACE polymorphisms (Insertion, Deletion or I/D) and essential hypertension in a population of Lima, Peru. Material and methods This is a study of cases (essential arterial hypertension) and controls, with determination of the ACE I/D genotype. Results Cases (65) and controls (39) had a mean age (standard deviation) of 74.3 (7.9) and 72.6 (6.5) (p = 0.24). In cases, the genotype frequencies DD, ID, and II were 6 (9.2%), 28 (43.1%) and 31 (47.7%), respectively. In controls, the genotype frequencies DD, ID, and II were 6 (15.4%), 14 (35.9%) and 19 (48.7%). The Hardy – Weinberg equilibrium analysis in cases and controls was p = 0.93 and p = 0.23, respectively. No significant associations between genotype DD vs ID+II (OR = 0.56, 95% CI 0.17-1.87, p = 0.34) or II vs DD+ID (OR = 0.95, 95% CI, 0.43 - 2.12, p = 0.92) and essential hypertension were found.

Abstract

Background: Epidemiological studies have shown an association between the ACE gene I / D polymorphism with arterial hypertension, specifically the DD genotype in different populations. The objective of this study is to evaluate the association between ACE polymorphisms (Insertion, Deletion or I/D) and essential hypertension in a population of Lima, Peru. Material and methods This is a study of cases (essential arterial hypertension) and controls, with determination of the ACE I/D genotype. Results Cases (65) and controls (39) had a mean age (standard deviation) of 74.3 (7.9) and 72.6 (6.5) (p = 0.24). In cases, the genotype frequencies DD, ID, and II were 6 (9.2%), 28 (43.1%) and 31 (47.7%), respectively. In controls, the genotype frequencies DD, ID, and II were 6 (15.4%), 14 (35.9%) and 19 (48.7%). The Hardy – Weinberg equilibrium analysis in cases and controls was p = 0.93 and p = 0.23, respectively. No significant associations between genotype DD vs ID+II (OR = 0.56, 95% CI 0.17-1.87, p = 0.34) or II vs DD+ID (OR = 0.95, 95% CI, 0.43 - 2.12, p = 0.92) and essential hypertension were found.

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Keywords

hypertension; renin-angiotensin system; genetic polymorphism; angiotensin converting enzyme; Peru

About this article
Title

LACK OF ASSOCIATION BETWEEN ANGIOTENSIN-CONVERTING ENZYME (ACE) GENOTYPE AND ESSENTIAL HYPERTENSION IN PERUVIAN OLDER PEOPLE

Journal

Arterial Hypertension

Issue

Ahead of print

Published online

2020-09-07

DOI

10.5603/AH.a2020.0011

Keywords

hypertension
renin-angiotensin system
genetic polymorphism
angiotensin converting enzyme
Peru

Authors

Teodoro J. Oscanoa
Edwin C. Cieza
Frank A. Lizaraso-Soto
María L. Guevara
Ricardo M. Fujita
Roman Romero-Ortuno

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