open access

Vol 18, No 4 (2014)
REVIEV
Published online: 2015-03-25
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Obesity-related hypertension

Marcin Adamczak, Damian Gojowy, Andrzej Więcek
Nadciśnienie tętnicze 2014;18(4):224-236.

open access

Vol 18, No 4 (2014)
REVIEV
Published online: 2015-03-25

Abstract

For nearly a century, it is known that hypertension and obesity often coexist. The pathogenetic mechanisms leading to hypertension in obese patients are complex. The most important are: sympathetic nervous system overactivation, increased sodium reabsorption in the renal tubules leading to hypervolemia, insulin resistance, stimulation of the renin-angiotensin- aldosterone system and disturbances of the adipokines secretion. The goal of antihypertensive therapy in obese subjects is to obtain blood pressure below 140/90 mm Hg. Basic methods of antihypertension treatment in obese patients is to reduce body fat mass by calorie restrictive diet and increased physical activity. Recommended for advanced obesity bariatric surgery may also exert an antihypertensive effect. In pharmacotherapy of hypertension in obese patients preferentially are angiotensin converting enzyme inhibitors or angiotensin II receptor antagonists. In order to obtain the target of blood pressure in these patients usually it is necessary to use two or more antihypertensive drugs.

Abstract

For nearly a century, it is known that hypertension and obesity often coexist. The pathogenetic mechanisms leading to hypertension in obese patients are complex. The most important are: sympathetic nervous system overactivation, increased sodium reabsorption in the renal tubules leading to hypervolemia, insulin resistance, stimulation of the renin-angiotensin- aldosterone system and disturbances of the adipokines secretion. The goal of antihypertensive therapy in obese subjects is to obtain blood pressure below 140/90 mm Hg. Basic methods of antihypertension treatment in obese patients is to reduce body fat mass by calorie restrictive diet and increased physical activity. Recommended for advanced obesity bariatric surgery may also exert an antihypertensive effect. In pharmacotherapy of hypertension in obese patients preferentially are angiotensin converting enzyme inhibitors or angiotensin II receptor antagonists. In order to obtain the target of blood pressure in these patients usually it is necessary to use two or more antihypertensive drugs.

Get Citation

Keywords

hypertension, obesity, obesity-related hypertension, antihypertensive treatment in obese patients

About this article
Title

Obesity-related hypertension

Journal

Arterial Hypertension

Issue

Vol 18, No 4 (2014)

Pages

224-236

Published online

2015-03-25

Bibliographic record

Nadciśnienie tętnicze 2014;18(4):224-236.

Keywords

hypertension
obesity
obesity-related hypertension
antihypertensive treatment in obese patients

Authors

Marcin Adamczak
Damian Gojowy
Andrzej Więcek

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