dostęp otwarty

Tom 19, Nr 1 (2015)
ORIGINAL PAPERS
Opublikowany online: 2015-03-31
Pobierz cytowanie

Renal tubulointerstitial tissue damage, central pressure and vascular function in patients with untreated primary arterial hypertension

Rafał Bednarski, Piotr Kubalski, Anna Stefańska, Grażyna Odrowąż-Sypniewska, Jacek Manitius
DOI: 10.5603/AH.2015.0006
·
Arterial Hypertension 2015;19(1):29-38.

dostęp otwarty

Tom 19, Nr 1 (2015)
ORIGINAL PAPERS
Opublikowany online: 2015-03-31

Streszczenie

Background The aim of the study was to examine the correlation of the conventional method of arterial pressure measurement in the brachial artery and non-invasive aortic pressure measurement by applanation tonometry with vascular and left ventricular structure and function. An attempt was made at determining a correlation of morphological and functional changes within the cardiovascular system with selected parameters of renal filtration function and the renal interstitium in patients with previously untreated primary arterial hypertension.
Material and methods 25 patients with untreated primary arterial hypertension without albuminuria and 15 healthy volunteers underwent arterial pressure measurement with a standard mercury sphygmomanometer using the Korotkoff technique and non-invasive measurement of aortic pressure by applanation tonometry using a SphygmoCor device. For all subjects, the concentrations of creatinine, uric acid, 1,25(OH)2D3, erythropoietin, and 25-hour NAG excretion were determined and GFR was estimated using the MDRD equation. PWV measurement was performed using a SphygmoCor device, whereas IMT was measured by ultrasound.
Results Hypertensive patients showed higher values of arterial pressure compared to the control group: SBP, DBP, PP, MAP, as well as CSP, CDP, CPP and MCAP. In both the studied and the control group, the following statistically significant positive correlations were found: CPP vs IMT and CPP vs AIx. Only in the studied group, the following positive linear correlations were found: NAG vs PWV (R = 0.46; p = 0.019); NAG vs IMT (R = 0.36; p = 0.078). In the multiple regression model, a statistically significant positive effect was found of PWV and IMT [PWV (b 0.41; p = 0.0158), IMT (b 0.49; p = 0.0048)] on the dependent variable NAG (R2 = 0.503) in hypertensive patients. eGFR or uric acid concentration in serum included additionally in the model had no statistically significant effect on the dependent variable NAG (p = 0.9307 and p = 0.4938, respectively).
Conclusions Damage to the renal tubulointerstitial tissue in hypertensive patients is concomitant with a decrease in vascular resistance. CPP may constitute a useful parameter for assessing the development of atherosclerotic lesions in vessels and the function of the left ventricle of the heart.

Streszczenie

Background The aim of the study was to examine the correlation of the conventional method of arterial pressure measurement in the brachial artery and non-invasive aortic pressure measurement by applanation tonometry with vascular and left ventricular structure and function. An attempt was made at determining a correlation of morphological and functional changes within the cardiovascular system with selected parameters of renal filtration function and the renal interstitium in patients with previously untreated primary arterial hypertension.
Material and methods 25 patients with untreated primary arterial hypertension without albuminuria and 15 healthy volunteers underwent arterial pressure measurement with a standard mercury sphygmomanometer using the Korotkoff technique and non-invasive measurement of aortic pressure by applanation tonometry using a SphygmoCor device. For all subjects, the concentrations of creatinine, uric acid, 1,25(OH)2D3, erythropoietin, and 25-hour NAG excretion were determined and GFR was estimated using the MDRD equation. PWV measurement was performed using a SphygmoCor device, whereas IMT was measured by ultrasound.
Results Hypertensive patients showed higher values of arterial pressure compared to the control group: SBP, DBP, PP, MAP, as well as CSP, CDP, CPP and MCAP. In both the studied and the control group, the following statistically significant positive correlations were found: CPP vs IMT and CPP vs AIx. Only in the studied group, the following positive linear correlations were found: NAG vs PWV (R = 0.46; p = 0.019); NAG vs IMT (R = 0.36; p = 0.078). In the multiple regression model, a statistically significant positive effect was found of PWV and IMT [PWV (b 0.41; p = 0.0158), IMT (b 0.49; p = 0.0048)] on the dependent variable NAG (R2 = 0.503) in hypertensive patients. eGFR or uric acid concentration in serum included additionally in the model had no statistically significant effect on the dependent variable NAG (p = 0.9307 and p = 0.4938, respectively).
Conclusions Damage to the renal tubulointerstitial tissue in hypertensive patients is concomitant with a decrease in vascular resistance. CPP may constitute a useful parameter for assessing the development of atherosclerotic lesions in vessels and the function of the left ventricle of the heart.
Pobierz cytowanie

Słowa kluczowe

arterial hypertension, CPP, NAG, vessels

Informacje o artykule
Tytuł

Renal tubulointerstitial tissue damage, central pressure and vascular function in patients with untreated primary arterial hypertension

Czasopismo

Arterial Hypertension

Numer

Tom 19, Nr 1 (2015)

Strony

29-38

Data publikacji on-line

2015-03-31

DOI

10.5603/AH.2015.0006

Rekord bibliograficzny

Arterial Hypertension 2015;19(1):29-38.

Słowa kluczowe

arterial hypertension
CPP
NAG
vessels

Autorzy

Rafał Bednarski
Piotr Kubalski
Anna Stefańska
Grażyna Odrowąż-Sypniewska
Jacek Manitius

Ważne: serwis https://journals.viamedica.pl/ wykorzystuje pliki cookies. Więcej >>

Używamy informacji zapisanych za pomocą plików cookies m.in. w celach statystycznych, dostosowania serwisu do potrzeb użytkownika (np. język interfejsu) i do obsługi logowania użytkowników. W ustawieniach przeglądarki internetowej można zmienić opcje dotyczące cookies. Korzystanie z serwisu bez zmiany ustawień dotyczących cookies oznacza, że będą one zapisane w pamięci komputera. Więcej informacji można znaleźć w naszej Polityce prywatności.

Czym są i do czego służą pliki cookie możesz dowiedzieć się na stronie wszystkoociasteczkach.pl.

Czasopismo Nadciśnienie Tętnicze dostęne jest również w Ikamed - księgarnia medyczna

Wydawcą serwisu jest "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl