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Standarized tomato extract — is an alternative to aspiryn in the primary prevention of cardiovascular disease in patients with hypertension
open access
Abstract
Tomatoes are an important source of bioactive compounds which can be divided into three groups: carotenoids, vitamins, phenols. Standardized tomato extract (STE) comprises of those chemicals in high concentrations which are obtained due to modern technologies. There have been many studies that have shown anti-inflammatory, antioxidant, anti-tumor and endothelium protective properties of carotenoids, the most important fact is that a diet rich in tomatoes may have a beneficial effect on the cardiovascular system by inhibiting platelet aggregation. Inhibiting platelet caused by ADP-, collagen, and arachidonic acid -related aggregation is mediated by decrease of releasing platelet factor 4 (PF4) or via increase of intracellular cAMP concentration. Active chemicals contained in STE may delay the occurrence of atherosclerotic lesions significantly.
Furthermore, recent studies have reported that a standardized extract of tomato has a blood pressure lowering properties due to the inhibitory activity of angiotensin I converting enzyme (ACE). Tomato extract due to the lack of interaction and side effects, and due to the effectiveness confirmed in the research might be an alternative antiplatelet prophylaxis option instead of ASA (acetylsalicylic acid) in primary prevention of cardiovascular disease, especially in those cases where ASA usage is related with risk of side effects.
In hypertensive patients STE may be considered in difficult-to-control hypertension, especially in high-risk group of patient with numerous risk factor, organ damage or comorbidites such as: diabetes mellitus, overweight or obesity. It should be emphasized that, the can be used as an additional therapy to aspirin and other antiplatelet drugs.
Abstract
Tomatoes are an important source of bioactive compounds which can be divided into three groups: carotenoids, vitamins, phenols. Standardized tomato extract (STE) comprises of those chemicals in high concentrations which are obtained due to modern technologies. There have been many studies that have shown anti-inflammatory, antioxidant, anti-tumor and endothelium protective properties of carotenoids, the most important fact is that a diet rich in tomatoes may have a beneficial effect on the cardiovascular system by inhibiting platelet aggregation. Inhibiting platelet caused by ADP-, collagen, and arachidonic acid -related aggregation is mediated by decrease of releasing platelet factor 4 (PF4) or via increase of intracellular cAMP concentration. Active chemicals contained in STE may delay the occurrence of atherosclerotic lesions significantly.
Furthermore, recent studies have reported that a standardized extract of tomato has a blood pressure lowering properties due to the inhibitory activity of angiotensin I converting enzyme (ACE). Tomato extract due to the lack of interaction and side effects, and due to the effectiveness confirmed in the research might be an alternative antiplatelet prophylaxis option instead of ASA (acetylsalicylic acid) in primary prevention of cardiovascular disease, especially in those cases where ASA usage is related with risk of side effects.
In hypertensive patients STE may be considered in difficult-to-control hypertension, especially in high-risk group of patient with numerous risk factor, organ damage or comorbidites such as: diabetes mellitus, overweight or obesity. It should be emphasized that, the can be used as an additional therapy to aspirin and other antiplatelet drugs.
Keywords
tomato extract, antyagregation, platelet, primary and secondary prevention, arterial hypertension
Title
Standarized tomato extract — is an alternative to aspiryn in the primary prevention of cardiovascular disease in patients with hypertension
Journal
Issue
Article type
Review paper
Pages
37-42
Published online
2014-09-19
Page views
3798
Article views/downloads
4969
Bibliographic record
Nadciśnienie tętnicze 2014;18(1):37-42.
Keywords
tomato extract
antyagregation
platelet
primary and secondary prevention
arterial hypertension
Authors
Angelika Miazga
Katarzyna Kostka-Jeziorny
Beata Begier-Krasińska
Andrzej Tykarski