open access

Vol 17, No 3 (2013)
REVIEV
Published online: 2013-09-09
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Patients with hypertension and dyslipidemia. The importance of antihypertensive and lipid-lowering combination therapy

Arkadiusz Niklas, Anna M. Piekarska, Andrzej Tykarski
Nadciśnienie tętnicze 2013;17(3):245-260.

open access

Vol 17, No 3 (2013)
REVIEV
Published online: 2013-09-09

Abstract

Hypertension is the major cause of death worldwide. InPoland about a third of people have high blood pressure,while more than two thirds population have abnormallevel of lipids. Low efficacy of the treatment may be dueto the long duration of treatment and number of dose.The use of fixed-dose drugs, once a day, promotes bettercompliance. This article reviews studies using the one-pillcombination of amlodipine and atorvastatin. This paperdiscusses the place of statins, particularly atorvastatinin lipid-lowering therapy and amlodipine — calciumantagonists in antihypertensive therapy. The article summarizesthe efficacy and safety of combination of amlodipineand atorvastatin in studies: ASCOT, AVALON,RESPOND, CUSP, DUAAL, GEMINI, JEWEL. Theresults show the effectiveness of this combination, reductionof blood pressure and LDL-cholesterol. The effectsof treatment resulted in a reduction of total cardiovascularrisk and mortality.

Abstract

Hypertension is the major cause of death worldwide. InPoland about a third of people have high blood pressure,while more than two thirds population have abnormallevel of lipids. Low efficacy of the treatment may be dueto the long duration of treatment and number of dose.The use of fixed-dose drugs, once a day, promotes bettercompliance. This article reviews studies using the one-pillcombination of amlodipine and atorvastatin. This paperdiscusses the place of statins, particularly atorvastatinin lipid-lowering therapy and amlodipine — calciumantagonists in antihypertensive therapy. The article summarizesthe efficacy and safety of combination of amlodipineand atorvastatin in studies: ASCOT, AVALON,RESPOND, CUSP, DUAAL, GEMINI, JEWEL. Theresults show the effectiveness of this combination, reductionof blood pressure and LDL-cholesterol. The effectsof treatment resulted in a reduction of total cardiovascularrisk and mortality.
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Keywords

amlodipine, atorvastatin, fixe dose combination, antihypertensive treatment

About this article
Title

Patients with hypertension and dyslipidemia. The importance of antihypertensive and lipid-lowering combination therapy

Journal

Arterial Hypertension

Issue

Vol 17, No 3 (2013)

Pages

245-260

Published online

2013-09-09

Bibliographic record

Nadciśnienie tętnicze 2013;17(3):245-260.

Keywords

amlodipine
atorvastatin
fixe dose combination
antihypertensive treatment

Authors

Arkadiusz Niklas
Anna M. Piekarska
Andrzej Tykarski

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