Ischemic heart disease and left ventricular hypertrophy, hypertension and lipid metabolism disturbances in hemodialysed patients

Abstract

Background Coronary heart disease is present in 70% hemodialysed patients and it is the main cause of sudden death. The aim of the study was the assessement the changes incoronary arteries and answer if risk factors: left ventricular hypertrophy, hypertension and lipid disturbances have the relations with development of CVD.

Material and methods In 37 hemodialysed patients coronarography, echocardiography, 24-hour blood pressure monitoring,laboratory analysis and serum level of nitric oxide were assessed. The patients were devided for 3 subgroups: in 7 were no changes in coronary arteries, in 12 coronary arteries were occluded, in 17 occluded and calcified.

Results In all patients left ventricular hypertrophy was presentand its systolic-diastolic dysfunction. Hypertension waspresent in 30 patients. It was no differences in blood pressurein 3 subgroups.

Conclusions The relations between coronary artery changesand echocardiographic parameters and serum level of nitricacid, between echoradiographic parameters and serum levelof cholesterol, time of dialysis therapy, patients age, blood pressure could confirm that this risk factors for cardiovascular events play also a role for development ischemic heart disease.