Vol 15, No 2 (2011)
Review paper
Published online: 2011-05-26
Effectiveness of essential hypertension treatment by obesity reduction (Does overweight loss always leads to blood pressure normalization?)
Anna Puszkarska, Jerzy Głuszek
Nadciśnienie tętnicze 2011;15(2):118-124.
Vol 15, No 2 (2011)
REVIEV
Published online: 2011-05-26
Abstract
Obesity and overweight are one of the fundamental health problems
of the contemporary world. The prevalence of obesity and
overweight in developed countries has reached 50% and is constantly
increasing. Visceral adipose tissue in obese subject releases
many biologically active substances which may play
a potential role in the pathogenesis of hypertension. These
active substances include: angiotensin II, tumour necrosis factor,
C-reactive protein, interleukin 6, resistin. Insulin resistance,
typical for obese people, increases sympathetic nervous
system activation and renal tubular sodium reabsorption. Epidemiological
and clinical studies clearly show the relationship
between obesity, overweight and prevalence of hypertension.
At the same time current studies show that reduction of body
mass leads to decrease or even normalization of blood pressure.
Unfortunately, in most of them the duration of observation
period was only 1 year or 2 years. There were only a few
studies in which patients had been observed for several years,
but the results were ambiguous. No data from long-term trials
are available. Thus, a great interest arouse by the reports
concerning long-term effect of bariatric surgery on blood pressure.
Obesity reduction by bariatric surgery decreases or normalizes
blood pressure values in majority of cases, but many
years after the operation blood pressure often increases again.
Arterial Hypertension 2011, vol. 15, no 2, pages 118–124.
Abstract
Obesity and overweight are one of the fundamental health problems
of the contemporary world. The prevalence of obesity and
overweight in developed countries has reached 50% and is constantly
increasing. Visceral adipose tissue in obese subject releases
many biologically active substances which may play
a potential role in the pathogenesis of hypertension. These
active substances include: angiotensin II, tumour necrosis factor,
C-reactive protein, interleukin 6, resistin. Insulin resistance,
typical for obese people, increases sympathetic nervous
system activation and renal tubular sodium reabsorption. Epidemiological
and clinical studies clearly show the relationship
between obesity, overweight and prevalence of hypertension.
At the same time current studies show that reduction of body
mass leads to decrease or even normalization of blood pressure.
Unfortunately, in most of them the duration of observation
period was only 1 year or 2 years. There were only a few
studies in which patients had been observed for several years,
but the results were ambiguous. No data from long-term trials
are available. Thus, a great interest arouse by the reports
concerning long-term effect of bariatric surgery on blood pressure.
Obesity reduction by bariatric surgery decreases or normalizes
blood pressure values in majority of cases, but many
years after the operation blood pressure often increases again.
Arterial Hypertension 2011, vol. 15, no 2, pages 118–124.
Keywords
obesity; overweight; hypertension; bariatric surgeon
Title
Effectiveness of essential hypertension treatment by obesity reduction (Does overweight loss always leads to blood pressure normalization?)
Journal
Arterial Hypertension
Issue
Vol 15, No 2 (2011)
Article type
Review paper
Pages
118-124
Published online
2011-05-26
Page views
748
Article views/downloads
2265
Bibliographic record
Nadciśnienie tętnicze 2011;15(2):118-124.
Keywords
obesity
overweight
hypertension
bariatric surgeon
Authors
Anna Puszkarska
Jerzy Głuszek
About this article