open access

Vol 15, No 4 (2011)
Prace oryginalne
Published online: 2011-10-05
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The relationship between ACE and angiotensinogen gene polymorphisms and visceral obesity, and left ventricular structure and function — a 10-year follow-up of young healthy males

Agnieszka Rojek, Marzena Chrostowska, Justyna Bigda, Ryszard Pawłowski, Maria Dudziak, Barbara Krupa-Wojciechowska, Krzysztof Narkiewicz
Nadciśnienie tętnicze 2011;15(4):242-250.

open access

Vol 15, No 4 (2011)
Prace oryginalne
Published online: 2011-10-05

Abstract

Background Genetic and environmental factors play a major role in the pathogenesis of hypertension. The aim of this study was to investigate whether the insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) gene and angiotensinogen (AGT) gene increase the susceptibility to abdominal obesity and affect left ventricular function and structure in a 10-year follow-up of a young healthy male population
Material and methods The study was carried out in a group of 68 normotensive subjects, aged 23 ± 3.5 years, mean ± SD. The subjects underwent the following procedures: anthropometric measurements, basic biochemical tests, office blood pressure measurements, ambulatory blood pressure measurements (ABPM), echocardiography. The I/D polymorphism within intron 16 of the ACE gene and AGT gene polymorphism (the allele M235T and T174M) were genotyped by polymerase chain reaction.
Results No relationship between waist circumference and ACE, AGT polymorphisms was observed. The structural changes of the heart differed significantly in T174M AGT TT genotype with increased septum/ /posterior wall ratio compared to TM and MM: (1.20 ± 0.12 v. 1.1 ± 0.11 cm; p < 0.05). The II genotype of ACE gene was associated with an elevated A wave peak velocity in transmitral flow (0.56 ± 0.17 v. 0.48 ± 0.08 m/s; p < 0.05). Blood pressure was not related to the ACE and AGT polymorphisms.
Conclusions In a healthy population, the ACE and AGT polymorphisms might contribute to the structural and functional changes of the heart, but not to development of abdominal obesity or hypertension.
Arterial Hypertension 2011, vol. 15, no 4, pages 242–250.

Abstract

Background Genetic and environmental factors play a major role in the pathogenesis of hypertension. The aim of this study was to investigate whether the insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) gene and angiotensinogen (AGT) gene increase the susceptibility to abdominal obesity and affect left ventricular function and structure in a 10-year follow-up of a young healthy male population
Material and methods The study was carried out in a group of 68 normotensive subjects, aged 23 ± 3.5 years, mean ± SD. The subjects underwent the following procedures: anthropometric measurements, basic biochemical tests, office blood pressure measurements, ambulatory blood pressure measurements (ABPM), echocardiography. The I/D polymorphism within intron 16 of the ACE gene and AGT gene polymorphism (the allele M235T and T174M) were genotyped by polymerase chain reaction.
Results No relationship between waist circumference and ACE, AGT polymorphisms was observed. The structural changes of the heart differed significantly in T174M AGT TT genotype with increased septum/ /posterior wall ratio compared to TM and MM: (1.20 ± 0.12 v. 1.1 ± 0.11 cm; p < 0.05). The II genotype of ACE gene was associated with an elevated A wave peak velocity in transmitral flow (0.56 ± 0.17 v. 0.48 ± 0.08 m/s; p < 0.05). Blood pressure was not related to the ACE and AGT polymorphisms.
Conclusions In a healthy population, the ACE and AGT polymorphisms might contribute to the structural and functional changes of the heart, but not to development of abdominal obesity or hypertension.
Arterial Hypertension 2011, vol. 15, no 4, pages 242–250.
Get Citation

Keywords

ACE polymorphism; AGT polymorphism; waist circumference; hypertension

About this article
Title

The relationship between ACE and angiotensinogen gene polymorphisms and visceral obesity, and left ventricular structure and function — a 10-year follow-up of young healthy males

Journal

Arterial Hypertension

Issue

Vol 15, No 4 (2011)

Pages

242-250

Published online

2011-10-05

Bibliographic record

Nadciśnienie tętnicze 2011;15(4):242-250.

Keywords

ACE polymorphism
AGT polymorphism
waist circumference
hypertension

Authors

Agnieszka Rojek
Marzena Chrostowska
Justyna Bigda
Ryszard Pawłowski
Maria Dudziak
Barbara Krupa-Wojciechowska
Krzysztof Narkiewicz

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