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The relationship between ACE and angiotensinogen gene polymorphisms and visceral obesity, and left ventricular structure and function — a 10-year follow-up of young healthy males
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Abstract
Material and methods The study was carried out in a group of 68 normotensive subjects, aged 23 ± 3.5 years, mean ± SD. The subjects underwent the following procedures: anthropometric measurements, basic biochemical tests, office blood pressure measurements, ambulatory blood pressure measurements (ABPM), echocardiography. The I/D polymorphism within intron 16 of the ACE gene and AGT gene polymorphism (the allele M235T and T174M) were genotyped by polymerase chain reaction.
Results No relationship between waist circumference and ACE, AGT polymorphisms was observed. The structural changes of the heart differed significantly in T174M AGT TT genotype with increased septum/ /posterior wall ratio compared to TM and MM: (1.20 ± 0.12 v. 1.1 ± 0.11 cm; p < 0.05). The II genotype of ACE gene was associated with an elevated A wave peak velocity in transmitral flow (0.56 ± 0.17 v. 0.48 ± 0.08 m/s; p < 0.05). Blood pressure was not related to the ACE and AGT polymorphisms.
Conclusions In a healthy population, the ACE and AGT polymorphisms might contribute to the structural and functional changes of the heart, but not to development of abdominal obesity or hypertension.
Arterial Hypertension 2011, vol. 15, no 4, pages 242–250.
Abstract
Material and methods The study was carried out in a group of 68 normotensive subjects, aged 23 ± 3.5 years, mean ± SD. The subjects underwent the following procedures: anthropometric measurements, basic biochemical tests, office blood pressure measurements, ambulatory blood pressure measurements (ABPM), echocardiography. The I/D polymorphism within intron 16 of the ACE gene and AGT gene polymorphism (the allele M235T and T174M) were genotyped by polymerase chain reaction.
Results No relationship between waist circumference and ACE, AGT polymorphisms was observed. The structural changes of the heart differed significantly in T174M AGT TT genotype with increased septum/ /posterior wall ratio compared to TM and MM: (1.20 ± 0.12 v. 1.1 ± 0.11 cm; p < 0.05). The II genotype of ACE gene was associated with an elevated A wave peak velocity in transmitral flow (0.56 ± 0.17 v. 0.48 ± 0.08 m/s; p < 0.05). Blood pressure was not related to the ACE and AGT polymorphisms.
Conclusions In a healthy population, the ACE and AGT polymorphisms might contribute to the structural and functional changes of the heart, but not to development of abdominal obesity or hypertension.
Arterial Hypertension 2011, vol. 15, no 4, pages 242–250.
Keywords
ACE polymorphism; AGT polymorphism; waist circumference; hypertension
About this articleTitle
The relationship between ACE and angiotensinogen gene polymorphisms and visceral obesity, and left ventricular structure and function — a 10-year follow-up of young healthy males
Journal
Issue
Article type
Original paper
Pages
242-250
Published online
2011-10-05
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934
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Bibliographic record
Nadciśnienie tętnicze 2011;15(4):242-250.
Keywords
ACE polymorphism
AGT polymorphism
waist circumference
hypertension
Authors
Agnieszka Rojek
Marzena Chrostowska
Justyna Bigda
Ryszard Pawłowski
Maria Dudziak
Barbara Krupa-Wojciechowska
Krzysztof Narkiewicz