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Does treatment with angiotensin converting enzyme inhibitor influence on insulin resistance connect with ACE gene insertion/deletion polymorphism?
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Abstract
Material and methods The study comprised 64 patients with mild-to-moderate essential hypertension (41 male and 23 female) without coexisting illness. The mean age of study group was 40.48 ± 16.39 years. Before treatment the blood samples for laboratory investigation and genetic analysis (polymerase chain reaction) were taken. Then patients received 4 mg perindopril once a day. After 4 weeks patients with poor blood pressure control received doubled dose of perindopril. Before treatment, after 4 weeks and after 8 weeks of treatment with ACE-I the blood pressure measurement with traditional method and ABPM were performed. After 8 weeks of treatment with ACE inhibitor further blood samples for laboratory investigation were taken.
Results The ACE genotype distribution was: II — n = 17 (27%), ID — n = 29 (45%), DD — n = 18 (28%). Any significant changes in insulin resistance after 8 weeks of treatment with ACE-I were not observed. But there is a negative correlation between insulin resistance before treatment and reduction of blood pressure in ABPM.
Conclusions Insulin resistance is independent on I/D polymorphism of ACE gene and does not change significantly after 2 months of treatment with perindopril. There is a negative correlation between basal insulin resistance and reduction of blood pressure in ABPM.
Arterial Hypertension 2011, vol. 15, no 5, pages 299–311
Abstract
Material and methods The study comprised 64 patients with mild-to-moderate essential hypertension (41 male and 23 female) without coexisting illness. The mean age of study group was 40.48 ± 16.39 years. Before treatment the blood samples for laboratory investigation and genetic analysis (polymerase chain reaction) were taken. Then patients received 4 mg perindopril once a day. After 4 weeks patients with poor blood pressure control received doubled dose of perindopril. Before treatment, after 4 weeks and after 8 weeks of treatment with ACE-I the blood pressure measurement with traditional method and ABPM were performed. After 8 weeks of treatment with ACE inhibitor further blood samples for laboratory investigation were taken.
Results The ACE genotype distribution was: II — n = 17 (27%), ID — n = 29 (45%), DD — n = 18 (28%). Any significant changes in insulin resistance after 8 weeks of treatment with ACE-I were not observed. But there is a negative correlation between insulin resistance before treatment and reduction of blood pressure in ABPM.
Conclusions Insulin resistance is independent on I/D polymorphism of ACE gene and does not change significantly after 2 months of treatment with perindopril. There is a negative correlation between basal insulin resistance and reduction of blood pressure in ABPM.
Arterial Hypertension 2011, vol. 15, no 5, pages 299–311
Keywords
hypertension; insertion/deletion polymorphism; ACE gene; insulin resistance
Title
Does treatment with angiotensin converting enzyme inhibitor influence on insulin resistance connect with ACE gene insertion/deletion polymorphism?
Journal
Issue
Article type
Original paper
Pages
299-311
Published online
2011-12-13
Page views
623
Article views/downloads
1509
Bibliographic record
Nadciśnienie tętnicze 2011;15(5):299-311.
Keywords
hypertension
insertion/deletion polymorphism
ACE gene
insulin resistance
Authors
Karolina Niklas
Arkadiusz Niklas
Jerzy Głuszek