Are products of visceral fat tissue — resistin and TNF-a — able to modulate blood pressure levels?

Abstract

Background Visceral fat tissue is the source of many important substances such as: resistin, tumor necrosis factor alpha (TNF-a) and many others. The aims of the study were to: 1. Estimate the concentrations of resistin, insulin, soluble receptors for TNF-a among patients with metabolic syndrome; 2. Assess insulin resistance according to HOMA index and estimate correlations between it and hypertension; 3. Investigate correlations between choosen adipocytokines, anthropometric parameters, insulin and hypertension.
Material and methods 85 patients with metabolic syndrome were investigated. Control group was 20 healthy volunteers. In both populations anthropological parameters such as body mass index (BMI), waist–hip ratio (WHR), were measured, concentration of resistin, insulin and soluble receptors for TNF-a in the blood had been also assessed.
Results had shown increased serum levels of resistin and STNFR1 and STNFR2. Insulin resistance, present in investigated group, was final effect of hyperresistinemia, elevated concentrations of STNFR1 and STNFR2. Results have also revealed connection between resistin, and soluble receptors for TNF-a, insulin resistance and values of blood pressure. Resistinemia and concentration of STNFR1 and STNFR2 correlated with values of blood pressure. It may suggest that adipocytokines can induce increase of systolic and diastolic blood pressure.
Conclusions 1. Patients with metabolic syndrome are characterized by many disorders connected with each other, such as hyperresistinemia and elevated levels of soluble receptors for TNF-a. 2. Insulin resistance presents in metabolic syndrome, correlates with chosen anthropometrics parameters and hypertension. 3. Concentration of adipocytokines modulate insulin resistance; resistin, STNFR1 and STNFR2 increase it; they also can increase the levels of blood pressure.