Is there a relationship among daily fructose intake, blood pressure and uric acid level in chronic kidney disease patients without diabetes?

Abstract

Background The fructose overconsumption from high fructose corn syrup may induce numeral direct and indirect undesirable clinical effects like hyperuricemia.
Material and methods The aim of the study was to reveal the relationship between fructose consumption — assessed with food frequency questionnaire, blood pressure control and some metabolic disturbances in 72 (age 52.0 ± 2.1; M/F 39/33) non-diabetic, chronic kidney disease stage 2–4 patients at out-patient basis. All of them were treated with antihypertensive drugs according to ESH/ESC guidelines.
The number of antihypertensive drugs: 3.70 ± 1.41.
Results We found significant linear correlation between estimated daily fructose consumption and uric acid level (r = 0.24; p < 0.05) and between the number of antihypertensive drugs and uric acid level (r = 0.30; p < 0.05). No correlation was found between estimated daily fructose consumption and number of antihypertensive drugs. Neither linear nor multiple regression correlations were found between the amount of daily fructose consumption and MAP, SBP, DBP and other factors such as:, BMI, age, sex, GFR, LDL-cholesterol, TG, urine protein excretion.
Conclusion The amount of consumed fructose may have the important influence on blood pressure regulation and effectiveness of its therapy in chronic kidney disease stage 2–4 patients.