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Is there a relationship among daily fructose intake, blood pressure and uric acid level in chronic kidney disease patients without diabetes?
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Abstract
Background The fructose overconsumption from high fructose corn syrup may induce numeral direct and indirect undesirable clinical effects like hyperuricemia.
Material and methods The aim of the study was to reveal the relationship between fructose consumption — assessed with food frequency questionnaire, blood pressure control and some metabolic disturbances in 72 (age 52.0 ± 2.1; M/F 39/33) non-diabetic, chronic kidney disease stage 2–4 patients at out-patient basis. All of them were treated with antihypertensive drugs according to ESH/ESC guidelines.
The number of antihypertensive drugs: 3.70 ± 1.41.
Results We found significant linear correlation between estimated daily fructose consumption and uric acid level (r = 0.24; p < 0.05) and between the number of antihypertensive drugs and uric acid level (r = 0.30; p < 0.05). No correlation was found between estimated daily fructose consumption and number of antihypertensive drugs. Neither linear nor multiple regression correlations were found between the amount of daily fructose consumption and MAP, SBP, DBP and other factors such as:, BMI, age, sex, GFR, LDL-cholesterol, TG, urine protein excretion.
Conclusion The amount of consumed fructose may have the important influence on blood pressure regulation and effectiveness of its therapy in chronic kidney disease stage 2–4 patients.
Abstract
Background The fructose overconsumption from high fructose corn syrup may induce numeral direct and indirect undesirable clinical effects like hyperuricemia.
Material and methods The aim of the study was to reveal the relationship between fructose consumption — assessed with food frequency questionnaire, blood pressure control and some metabolic disturbances in 72 (age 52.0 ± 2.1; M/F 39/33) non-diabetic, chronic kidney disease stage 2–4 patients at out-patient basis. All of them were treated with antihypertensive drugs according to ESH/ESC guidelines.
The number of antihypertensive drugs: 3.70 ± 1.41.
Results We found significant linear correlation between estimated daily fructose consumption and uric acid level (r = 0.24; p < 0.05) and between the number of antihypertensive drugs and uric acid level (r = 0.30; p < 0.05). No correlation was found between estimated daily fructose consumption and number of antihypertensive drugs. Neither linear nor multiple regression correlations were found between the amount of daily fructose consumption and MAP, SBP, DBP and other factors such as:, BMI, age, sex, GFR, LDL-cholesterol, TG, urine protein excretion.
Conclusion The amount of consumed fructose may have the important influence on blood pressure regulation and effectiveness of its therapy in chronic kidney disease stage 2–4 patients.
Keywords
fructose; uric acid; hypertension; chronic kidney disease
About this articleTitle
Is there a relationship among daily fructose intake, blood pressure and uric acid level in chronic kidney disease patients without diabetes?
Journal
Issue
Article type
Original paper
Pages
341-346
Published online
2012-02-23
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884
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5626
Bibliographic record
Nadciśnienie tętnicze 2011;15(6):341-346.
Keywords
fructose
uric acid
hypertension
chronic kidney disease
Authors
Marek Kretowicz
Grażyna Goszka
Andrzej Brymora
Mariusz Flisiński
Grażyna Odrowąż-Sypniewska
Jacek Manitius