Vol 1, No 2 (1997)
Prace oryginalne
Published online: 2000-03-08
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Angiotensin connerting enzyme activity in patients with primary hypertension in dependence on heart failure stage

Halina Adamska-Dyniewska, Zygmunt Zdrojewicz, Zbigniew Pieloch
Nadciśnienie tętnicze 1997;1(2):46-50.
Vol 1, No 2 (1997)
Prace oryginalne
Published online: 2000-03-08

Abstract


Background The aim of the study was to compare the serum activity of angiotensin convertase in healthy subjects and in hypertensive patients with or without advanced heart failure.
Methods Three groups were studied: A - 69 healthy subjects, B - 55 hypertensive patients without advanced heart failure (I-II NYHA stage) and C - 13 hypertensive patients with advanced heart failure (III-IV NYHA stage). The activity of angiotensin convertase in serum was determined by spectrofluorometric method (Friedland and Silverstein).
Results In healthy subjects the mean activity of angiotensin convertase in serum was 38,6 ± 8,1, in the group B - 42,0 ± 15,0 and in the group
C - 30,8 ± 10,5 nmol/ml/min. In the group B angiotensin convertase values shows nongaussian distribu- tion, and frequency of high values (40 nmol/ml/min) was greater than in group A (54 vs 36%,p.). In the group C high values of angiotensin convertase were not so frequent as in the group A (15% vs 36 %) and B (s 15% vs 54%).
Conclusions The distribution of serum angiotensin convertase activity has twomodal character. The percentage of persons with high values of angiotensin convertase ( > 40 nmol /ml/min) is higher in hypertensive patients without significant heart failure than in healthy subjects. When hypertension is associated with advanced heart failure (III-IV NYHA stage), then the percentage of high values of enzyme in serum is low.

Abstract


Background The aim of the study was to compare the serum activity of angiotensin convertase in healthy subjects and in hypertensive patients with or without advanced heart failure.
Methods Three groups were studied: A - 69 healthy subjects, B - 55 hypertensive patients without advanced heart failure (I-II NYHA stage) and C - 13 hypertensive patients with advanced heart failure (III-IV NYHA stage). The activity of angiotensin convertase in serum was determined by spectrofluorometric method (Friedland and Silverstein).
Results In healthy subjects the mean activity of angiotensin convertase in serum was 38,6 ± 8,1, in the group B - 42,0 ± 15,0 and in the group
C - 30,8 ± 10,5 nmol/ml/min. In the group B angiotensin convertase values shows nongaussian distribu- tion, and frequency of high values (40 nmol/ml/min) was greater than in group A (54 vs 36%,p.). In the group C high values of angiotensin convertase were not so frequent as in the group A (15% vs 36 %) and B (s 15% vs 54%).
Conclusions The distribution of serum angiotensin convertase activity has twomodal character. The percentage of persons with high values of angiotensin convertase ( > 40 nmol /ml/min) is higher in hypertensive patients without significant heart failure than in healthy subjects. When hypertension is associated with advanced heart failure (III-IV NYHA stage), then the percentage of high values of enzyme in serum is low.
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Keywords

primary hypertension mild and moderate; heart failure; angiotensin convertase activity

About this article
Title

Angiotensin connerting enzyme activity in patients with primary hypertension in dependence on heart failure stage

Journal

Arterial Hypertension

Issue

Vol 1, No 2 (1997)

Pages

46-50

Published online

2000-03-08

Bibliographic record

Nadciśnienie tętnicze 1997;1(2):46-50.

Keywords

primary hypertension mild and moderate
heart failure
angiotensin convertase activity

Authors

Halina Adamska-Dyniewska
Zygmunt Zdrojewicz
Zbigniew Pieloch

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