Cummulation of coronary artery disease risk factors in arterial hypertension

Abstract

Background There are many metabolic and humoral risk factors that coexist with arterial hypertension. Therefore the cardiovascular risk due to the elevated blood pressure is not limited only to the haemodynamic disturbances. The aim of our study was to estimate the distribution of the atherosclerosis risk factors distribution and the global risk of coronary events according to the blood pressure level.
Methods The study group consisted of 926 persons (751 men and 175 women), mean age 44 ± 9 years. We have measured in the serum glucose, total cholesterol, HDL cholesterol and triglycerides levels and calculated the LDL cholesterol level and the total cholesterol to HDL cholesterol ratio. The arterial blood pressure, weight, height, waist and hip circumference were also measured. We have calculated the body mass index and the waist-hip ratio. In each case the 12 lead ecg was performed. The risk of coronary events was calculated by means of Coronary Risk Assessor using the data base from the Framingham Heart Study. The population was divided into blood pressure groups according to ISH recommendations.
Results The mean global risk of coronary event during the next 10 years was 6.8% in the normotensive group, 11.9% in the mild hypertension and 17.1% in the moderate and severe hypertension group (p < 0.01).
Conclusions There is a considerable possibility of the coronary event risk reduction in the examined population, particularly in the hypertensive patients.